Stroke; a journal of cerebral circulation
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Randomized Controlled Trial
Carotid stenting: is there an operator effect? A pooled analysis from the carotid stenting trialists' collaboration.
Randomized clinical trials show higher 30-day risk of stroke or death after carotid artery stenting compared with surgery. We examined whether operator experience is associated with 30-day risk of stroke or death in the Carotid Stenting Trialists' Collaboration database. ⋯ Carotid stenting should only be performed by operators with annual procedure volume ≥6 cases per year.
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Randomized Controlled Trial
Mild hypothermia after intravenous thrombolysis in patients with acute stroke: a randomized controlled trial.
Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT00987922.
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Randomized Controlled Trial
Subarachnoid extension of intracerebral hemorrhage and 90-day outcomes in INTERACT2.
The prognostic significance of subarachnoid extension of intracerebral hemorrhage was determined in the INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT2) study. ⋯ URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.
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Randomized Controlled Trial
Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial.
Remote ischemic preconditioning is neuroprotective in models of acute cerebral ischemia. We tested the effect of prehospital rPerC as an adjunct to treatment with intravenous alteplase in patients with acute ischemic stroke. ⋯ URL: http://www.clinicaltrials.gov. Unique identifier: NCT00975962.
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Randomized Controlled Trial
Time to brain imaging in acute stroke is improving: secondary analysis of the INSTINCT trial.
Patients with acute ischemic stroke benefit from rapid evaluation and treatment, and timely brain imaging is a necessary component. We determined the effect of a targeted behavioral intervention on door-to-imaging time (DIT) among patients with ischemic stroke treated with tissue-type plasminogen activator. Second, we examined the variation in DIT accounted for by patient-level and hospital-level factors. ⋯ Performance on DIT improved similarly in intervention and control hospitals, suggesting that nonintervention factors explain the improvement. Hospital-level factors explain a modest proportion of variation in DIT, but further research is needed to identify the hospital-level factors responsible.