European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Jan 1982
Randomized Controlled Trial Clinical TrialThe use of pain scales in assessing the efficacy of analgesics in post-operative dental pain.
Two 10 cm visual analogue scales were compared with a 0-10 point numerical rating scale and a four-point verbal descriptive scale, in assessing pain severity in twelve patients with post-operative pain following removal of an impacted lower third molar. High correlations were shown between the pain scores from the two visual analogue scales and the numerical scale, but a lower correlation was obtained when the four-point scale was compared with the other scales. Analgesic efficacy was found to be dependent on the type of scale used. The 10 cm visual analogue scale was more sensitive than other pain scales and could discriminate between small changes in pain intensity.
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Eur. J. Clin. Pharmacol. · Jan 1981
Randomized Controlled Trial Clinical TrialPharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain.
A double-blind, randomised, crossover trial was undertaken to compare the analgesic effects of a single dose of paracetamol (1000 mg i.v.) with placebo in the immediate post-operative period following removal of impacted lower third molars. There was no significant difference in the pain relief between paracetamol and placebo in the first hour following injection. ⋯ Plasma concentrations of paracetamol were measured and pharmacokinetic variables were determined. Over the four hour period of investigation there was no clear relationship between analgesia and paracetamol concentration in either central or peripheral compartments.
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Eur. J. Clin. Pharmacol. · Mar 1976
Randomized Controlled Trial Comparative Study Clinical TrialEffect of paracetamol, mephenoxalone and their combination on pain following bone surgery.
Sixty patients suffering moderate postoperative pain after bone surgery were divided randomly into 3 treatment groups on the day following operation. Under double blind conditions they received either 400 mg mephenoxalone, a weak sedative, or 900 mg paracetamol, or the same doses of these drugs simultaneously, three times daily for three days. ⋯ However, during repeated administration over 3 days, the mean effect of the drug combination was slightly better than that of paracetamol or mephenoxalone alone. The drug combination did not induce more sedation or gastrointestinal side effects than either drug alone.