The Journal of allergy and clinical immunology
-
J. Allergy Clin. Immunol. · Oct 2010
Randomized Controlled TrialStatins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase.
We have previously shown that inhaled corticosteroids activate indoleamine 2, 3-dioxygenase (IDO) activity through increased IL-10 secretion. Statins might enhance the anti-inflammatory effects of corticosteroids. ⋯ A statin enhances the anti-inflammatory effect of an inhaled corticosteroid in asthma, and this was mediated through the alteration of IDO activity in macrophages.
-
J. Allergy Clin. Immunol. · Aug 2010
Letter Randomized Controlled Trial Multicenter StudyRisk of cataracts in the Childhood Asthma Management Program Cohort.
-
J. Allergy Clin. Immunol. · Jul 2010
Randomized Controlled Trial Multicenter StudySerum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study.
Asthma exacerbations, most often caused by respiratory tract infections, are the leading causes of asthma morbidity and comprise a significant proportion of asthma-related costs. Vitamin D status might play a role in preventing asthma exacerbations. ⋯ Vitamin D insufficiency is common in this population of North American children with mild-to-moderate persistent asthma and is associated with higher odds of severe exacerbation over a 4-year period.
-
J. Allergy Clin. Immunol. · Mar 2010
Randomized Controlled TrialThe effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria.
H(1)-antihistamines are first line treatment of chronic urticaria, but many patients do not get satisfactory relief with recommended doses. European guidelines recommend increased antihistamine doses of up to 4-fold. ⋯ Increasing the dosage of levocetirizine and desloratadine up to 4-fold improves chronic urticaria symptoms without compromising safety in approximately three quarters of patients with difficult-to-treat chronic urticaria.
-
J. Allergy Clin. Immunol. · Feb 2010
Randomized Controlled TrialEffects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma.
Combining inhaled corticosteroids with long-acting beta(2)-agonists results in improved asthma symptom control and fewer asthma exacerbations compared with those seen after inhaled corticosteroids alone. However, there are limited data as to whether these beneficial effects are due to enhanced anti-inflammatory actions or whether such combination therapies affect airway remodeling in patients with asthma. ⋯ The effects on allergen-induced changes in sputum eosinophils, airway myofibroblast numbers, and smooth muscle seen with combination therapy suggest that the benefits associated with this treatment might relate to effects on airway inflammation and remodeling. The attenuation of early asthmatic responses and airway hyperresponsiveness by combination treatment was likely due to the known functional antagonistic effect of formoterol.