The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jan 2007
Randomized Controlled TrialEgg oral immunotherapy in nonanaphylactic children with egg allergy.
There is no current active treatment for food allergy. Traditional injection immunotherapy has been proved unsafe, and thus there is a need for other forms of immunotherapy. ⋯ Use of allergen-specific OIT to protect subjects with food allergy from reaction on accidental ingestion would represent a significant paradigm change in the treatment of food allergy.
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J. Allergy Clin. Immunol. · Oct 2006
Randomized Controlled TrialSalmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma.
Recent studies suggest that there might be an association between albuterol use and worsening asthma in patients homozygous for arginine (Arg/Arg) at codon 16 of the beta-receptor. However, it is not known whether similar responses occur in Arg/Arg patients receiving long-acting beta2-agonists. ⋯ Analyses from this study indicate that genetic polymorphisms leading to Arg16Gly sequence changes within the beta2-adrenergic receptor do not affect patients' responses to recommended asthma therapy with salmeterol and fluticasone propionate.
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J. Allergy Clin. Immunol. · Jun 2006
Randomized Controlled TrialBronchodilator responses in Chinese children from asthma index families and the general population.
Although airway hyperresponsiveness to bronchoconstrictors has been extensively investigated, epidemiologic studies on airway hyperresponsiveness to bronchodilators are limited. ⋯ Because BDR can be affected by multiple factors, interpretation of clinical or research findings on BDR needs to take these factors into consideration.
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J. Allergy Clin. Immunol. · Apr 2006
Randomized Controlled TrialEffect of codeine on objective measurement of cough in chronic obstructive pulmonary disease.
Codeine is the standard antitussive treatment to which novel agents are compared. Little is known about the objective effect of any treatments on cough in chronic obstructive pulmonary disease (COPD). ⋯ Codeine is the antitussive agent to which we compare new treatments; however, in a group of stable patients with COPD, it had no effect on cough frequency over placebo.
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J. Allergy Clin. Immunol. · Apr 2006
Randomized Controlled Trial Multicenter StudySublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis.
Specific immunotherapy is the only treatment modality that has the potential to alter the natural course of allergic diseases. Sublingual immunotherapy has been developed to facilitate access to this form of treatment and to minimize serious adverse events. ⋯ For patients with grass pollen allergy, sublingual immunotherapy is well tolerated and can reduce symptoms and improve quality of life.