The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · May 2001
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialAddition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbations.
Adding salmeterol to low-dose fluticasone propionate (FP) produces greater improvements in pulmonary function and symptom control than increasing the dose of FP in patients who remain symptomatic with low-dose FP. ⋯ Salmeterol plus low-dose FP was more effective than higher dose FP alone in reducing asthma exacerbations in patients with persistent asthma. The ability to detect deteriorating asthma and the severity of exacerbation was similar between groups.
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J. Allergy Clin. Immunol. · Nov 2000
Randomized Controlled Trial Multicenter Study Clinical TrialMulticenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate.
The frequency of reactions reported to occur after the consumption of monosodium glutamate (MSG) is the subject of controversy. ⋯ The results suggest that large doses of MSG given without food may elicit more symptoms than a placebo in individuals who believe that they react adversely to MSG. However, neither persistent nor serious effects from MSG ingestion are observed, and the responses were not consistent on retesting.
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J. Allergy Clin. Immunol. · Jun 2000
Randomized Controlled Trial Clinical TrialSalmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: a randomized, double-blind, placebo-controlled trial.
Many patients with persistent asthma need both long-acting bronchodilators and inhaled corticosteroids for optimal asthma control. ⋯ Salmeterol 50 microg and fluticasone 100 microg combined in the Diskus powder delivery device offers significant clinical advantages over salmeterol or fluticasone alone at the same doses.
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J. Allergy Clin. Immunol. · May 2000
Randomized Controlled Trial Clinical TrialOutdated EpiPen and EpiPen Jr autoinjectors: past their prime?
EpiPen and EpiPen Jr autoinjectors are often recommended for prehospital treatment of anaphylaxis. When these units become outdated, there may be a delay in replacing them. ⋯ For prehospital treatment of anaphylaxis, we recommend the use of EpiPen and EpiPen Jr autoinjectors that are not outdated. If, however, the only autoinjector available is an outdated one, it could be used as long as no discoloration or precipitates are apparent because the potential benefit of using it is greater than the potential risk of a suboptimal epinephrine dose or of no epinephrine treatment at all.
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J. Allergy Clin. Immunol. · Nov 1999
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis.
Fexofenadine hydrochloride (HCl) is a new H(1) antihistamine used twice daily in some countries. ⋯ Once-daily fexofenadine is thus a valuable addition to the nonsedating group of H(1) receptor antagonists currently available for the treatment of seasonal allergic rhinitis.