The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jul 2017
Randomized Controlled Trial Multicenter StudyA randomized multicenter study evaluating Xolair persistence of response after long-term therapy.
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J. Allergy Clin. Immunol. · Jul 2017
Randomized Controlled TrialEffect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema.
The B2 receptor antagonist icatibant is approved for treatment of attacks of hereditary angioedema. Icatibant has been reported to decrease time-to-resolution of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema in 1 study of European patients. ⋯ This study does not support clinical efficacy of a bradykinin B2 receptor antagonist in ACE inhibitor-associated angioedema.
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J. Allergy Clin. Immunol. · Mar 2017
Randomized Controlled TrialAberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development.
Although a reduced gut microbiota diversity and low mucosal total IgA levels in infancy have been associated with allergy development, IgA responses to the gut microbiota have not yet been studied. ⋯ An aberrant IgA responsiveness to the gut microbiota during infancy precedes asthma and allergy development, possibly indicating an impaired mucosal barrier function in allergic children.
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J. Allergy Clin. Immunol. · Jun 2016
Randomized Controlled TrialNo long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine.
A randomized controlled trial in Fiji examined the immunogenicity and effect on nasopharyngeal carriage after 0, 1, 2, or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7; Prevnar) in infancy followed by 23-valent pneumococcal polysaccharide vaccine (23vPPV; Pneumovax) at 12 months of age. At 18 months of age, children given 23vPPV exhibited immune hyporesponsiveness to a micro-23vPPV (20%) challenge dose in terms of serotype-specific IgG and opsonophagocytosis, while 23vPPV had no effect on vaccine-type carriage. ⋯ Immune hyporesponsiveness induced by 23vPPV in toddlers does not appear to be sustained among preschool children in this context and does not affect the pneumococcal carriage rate in this age group.
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J. Allergy Clin. Immunol. · Mar 2016
Randomized Controlled Trial Clinical TrialEffects of formoterol or salmeterol on impulse oscillometry in patients with persistent asthma.
Effects of small-particle long-acting β-agonists on the small airways have been poorly documented. ⋯ Significant improvements in IOS outcomes but not spirometry results occurred after chronic dosing with formoterol compared with salmeterol. This might reflect better deposition to the entire lung, including the small airways.