The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jul 2011
Randomized Controlled Trial Multicenter StudyEfficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase.
A subgroup of patients with chronic spontaneous urticaria (CU) exhibits IgE antibodies directed against autoantigens, such as thyroperoxidase (TPO). We conducted this study to investigate whether such patients with CU with IgE against TPO benefit from treatment with omalizumab, a humanized anti-IgE mAb licensed for the treatment of severe persistent allergic (IgE-mediated) asthma. ⋯ The results of this study indicate that omalizumab is an effective treatment option for patients with CU with IgE autoantibodies against TPO who are refractory to conventional treatment.
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J. Allergy Clin. Immunol. · Jun 2011
Multicenter Study Comparative StudyObesity and asthma: an association modified by age of asthma onset.
Studies of asthma phenotypes have identified obesity as a component of a group characterized by a high proportion of subjects with adult-onset asthma. However, whether age of asthma onset modifies the association between obesity and asthma is unknown. ⋯ Asthmatic subjects are differentially affected by obesity based on whether they had asthma early (<12 years of age) or later in life. These results highlight the need to understand obesity as a comorbidity that affects specific clinical phenotypes and not all asthma subjects alike.
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J. Allergy Clin. Immunol. · Aug 2010
Letter Randomized Controlled Trial Multicenter StudyRisk of cataracts in the Childhood Asthma Management Program Cohort.
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J. Allergy Clin. Immunol. · Aug 2010
Multicenter Study Comparative Study Clinical TrialThe effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children.
Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal relationship between this and an atopic diathesis. ⋯ Respiratory syncytial virus prophylaxis in nonatopic children decreases by 80% the relative risk of recurrent wheezing but does not have any effect in infants with an atopic family history. This suggests that RSV predisposes to recurrent wheezing in an atopy-independent mechanism.
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J. Allergy Clin. Immunol. · Jul 2010
Randomized Controlled Trial Multicenter StudySerum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study.
Asthma exacerbations, most often caused by respiratory tract infections, are the leading causes of asthma morbidity and comprise a significant proportion of asthma-related costs. Vitamin D status might play a role in preventing asthma exacerbations. ⋯ Vitamin D insufficiency is common in this population of North American children with mild-to-moderate persistent asthma and is associated with higher odds of severe exacerbation over a 4-year period.