Plastic and reconstructive surgery
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Plast. Reconstr. Surg. · Mar 2014
Meta AnalysisKetorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials.
Postoperative pain control is essential for optimal patient outcomes. Ketorolac is an attractive alternative for achieving pain control postoperatively, but concerns over postoperative bleeding have limited its use. ⋯ Therapeutic, II.
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Plast. Reconstr. Surg. · Mar 2014
Determining the Michigan Hand Outcomes Questionnaire minimal clinically important difference by means of three methods.
To interpret patient-rated outcome measures, clinicians rely on the minimal clinically important difference. The authors studied the range of minimal clinically important difference scores for the overall Michigan Hand Outcomes Questionnaire score its and subscales in a population with various diagnoses and treatments. ⋯ The minimal clinically important difference for the overall Michigan Hand Outcomes Questionnaire score in atraumatic hand/forearm conditions falls between 8 and 13. Multiple analytic methods produce nonidentical but similar minimal clinically important differences. The authors recommend using difference estimates in these ranges when planning a clinical trial to investigate hand/forearm function across a range of diagnoses and treatments.
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Plast. Reconstr. Surg. · Mar 2014
Transplantation of the LGR6+ epithelial stem cell into full-thickness cutaneous wounds results in enhanced healing, nascent hair follicle development, and augmentation of angiogenic analytes.
The recently discovered leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6+) epithelial stem cell located within the follicular bulge of the adnexal compartment is capable of producing all cellular lineages of the skin. In this study, the authors sought to determine whether these cells can be transplanted for use as a type of cellular therapy for the repair of full-thickness wounds in which the native stem cell niche has been obliterated. ⋯ The LGR6+ epithelial stem cells appear to hold great promise for the development of a clinically useful stem cell–based therapy for the repair of full-thickness wounds and hair regeneration. These results indicate that transplantation of LGR6+ epithelial stem cells promotes epithelialization, hair growth, and angiogenesis in tissues destined for scar formation.