Anesthesia and analgesia
-
Anesthesia and analgesia · Jun 1989
Comparative StudyComparison of bupivacaine- and ropivacaine-induced conduction blockade in the isolated rabbit vagus nerve.
Ropivacaine (LEA-103) is a new amino-amide local anesthetic agent the chemical structure and anesthetic properties of which are similar to bupivacaine. Preliminary studies in animals indicate that the CNS toxicities of ropivacaine and bupivacaine are similar, but that ropivacaine may have less arrhythmogenic effects than bupivacaine. The current study arrhythmogenic effects than bupivacaine. ⋯ Thus, at the concentrations tested, ropivacaine appears to produce relatively less blockade of motor fibers than does bupivacaine but with similar sensory blockade. The onset of this difference became significant as early as five minutes after the drug exposure was begun. No significant differences in recovery times were observed.
-
The wall temperatures of the absorptive chambers of a divided soda lime canister were measured in 70 patients to determine the relationship between the difference in temperature of the two chambers and CO2 passage through the first chamber. CO2 passage through the first chamber was detected when the temperature of the second chamber became equal to that of the first. ⋯ When the maximal absorptive capacity of soda lime was reached, the pH of the surface of soda lime granules was still too high to change the indicator color. Exhaustion of soda lime is more reliably recognized by measuring wall temperatures of the chambers than by observing color change of the soda lime granules.