Anesthesia and analgesia
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Anesthesia and analgesia · Aug 1989
Esmolol for potentiation of nitroprusside-induced hypotension: impact on the cardiovascular, adrenergic, and renin-angiotensin systems in man.
Esmolol infusion at rates of 200, 300, and 400 micrograms.kg-1.min-1 was used to potentiate hypotension (mean arterial pressure = 60 mm Hg) induced with sodium nitroprusside (SNP) in 10 male patients undergoing radical cancer surgery during nitrous oxide-oxygen and fentanyl anesthesia. Heart rate (HR), blood pressure (radial arterial catheter), and plasma levels of renin activity (PRA), norepinephrine (N), epinephrine (E), and dopamine (D) were measured: 1) while patients were awake; 2) after induction of anesthesia (nitrous oxide, 60% in oxygen, fentanyl = 5 micrograms/kg followed by an infusion at 10 micrograms.kg-1.hr-1); 3) after surgery had begun; 4) after 20 minutes of SNP-induced hypotension; 5) after 20 minutes of esmolol at each of the above infusion rates; and 6) after the completion of surgery. ⋯ At 200 micrograms.kg-1.min-1, SNP requirement was 2.1 micrograms.kg-1.min-1 +/- 0.4, at 300 micrograms.kg-1.min-1, it was 1.0 micrograms.kg-1.min-1 +/- 0.2, and at 400 micrograms.kg-1.min-1, was 0.5 micrograms.kg-1.min-1 +/- 0.3. Concomitant with the decrease in SNP requirement, there were significant reductions in HR and PRA at all infusion rates of esmolol.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthesia and analgesia · Aug 1989
Randomized Controlled Trial Clinical TrialEarly postoperative arterial oxygen desaturation. Determining factors and response to oxygen therapy.
Oxygen arterial saturation (SaO2) was measured with a pulse oximeter in 209 patients after elective surgery. Measurements were made upon arrival in the recovery room (RR) and 1 hr later. On each occasion, the patients randomly and alternately breathed--for 10 min at a time--room air or 35% O2. ⋯ Postoperative hypoxemia (SaO2 less than or equal to 90%) after breathing room air for 10 min at 10 min, 20 min, and 1 hr after arrival in the RR occurred in 43.8%, 26.9%, and 16.9% of the patients, respectively. Breathing 35% O2 for 10 min 10 min after arrival in the RR, as well as 20 min and 1 hr after arrival, significantly increased SaO2 above the SaO2 level after breathing room air by 5.7% (P less than 0.001), 4.3% (P less than 0.001), and 4.0% (P less than 0.001), respectively. A significant multiple correlation was found between low SaO2 levels while breathing room air on arrival in the RR and fentanyl dose, age, and concentration of halothane used intraoperatively (R = 0.46; P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthesia and analgesia · Aug 1989
Letter Case ReportsInability to thread epidural catheter through epidural needle.
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Anesthesia and analgesia · Aug 1989
Randomized Controlled Trial Clinical TrialIntraoperative temperature monitoring sites in infants and children and the effect of inspired gas warming on esophageal temperature.
This study tested the hypotheses that 1) temperatures of "central" sites are similar in infants and children undergoing noncardiac surgery and 2) airway heating and humidification increases distal esophageal temperature. Twenty children were randomly assigned to receive 1) active airway humidification using an airway heater and humidifier set at 37 degrees C (N = 8), 2) passive airway humidification using a heat and moisture exchanger (N = 6), or 3) no airway humidification and/or heating (control, N = 6). There were no statistically significant differences between tympanic membrane, esophageal, rectal, and axillary temperatures. ⋯ Although esophageal and tympanic membrane temperatures in the entire group were similar, esophageal temperatures in patients receiving active and passive airway humidification were about 0.35 degrees C above tympanic temperatures after induction of anesthesia. In contrast, esophageal temperatures in patients without airway humidification were 0.25 degrees C below tympanic temperatures after induction of anesthesia. Esophageal-tympanic membrane temperature differences in the patients given active and passive humidification differed significantly from the corresponding sum in the control group at all times, but not from each other.
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Anesthesia and analgesia · Aug 1989
Randomized Controlled Trial Clinical TrialNormovolemic hemodilution and lumbar epidural anesthesia.
This randomized study was designed to determine the cardiovascular effects of normovolemic hemodilution and lumbar epidural anesthesia in patients scheduled for vascular surgery. The patients were randomly assigned to three different groups: group 1 (N = 10) included patients undergoing lumbar epidural anesthesia without hemodilution; group 2 (N = 10) consisted of patients with normovolemic hemodilution without epidural anesthesia; and in group 3 (N = 10) normovolemic hemodilution was produced during lumbar epidural anesthesia. The three groups included several patients with a history of either myocardial infarction or stable mild angina or treated and controlled hypertension. ⋯ After normovolemic hemodilution, hemoglobin concentration decreased significantly (15%), whereas cardiac index increased significantly (15%) without significant changes either in mean arterial pressure or in heart rate. Systemic oxygen transport and total body oxygen consumption did not change significantly. No patient experienced chest pain or electrocardiographic evidence of myocardial ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)