Anesthesia and analgesia
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Anesthesia and analgesia · Jan 1990
Labetalol and esmolol in the control of hypertension after intracranial surgery.
The postoperative course of patients emerging from general anesthesia after intracranial surgery is frequently complicated by hypertension. This study examined the comparative efficacy of esmolol and labetalol in treating increases in blood pressure during emergence and recovery from anesthesia after intracranial surgery. ⋯ However, decreases in heart rate were significantly more frequent in the immediate postoperative period in patients given labetalol. An increase in blood pressure after intracranial surgery appears to be a transitory phenomenon adequately treated with a short-acting antihypertensive agent such as esmolol.
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Anesthesia and analgesia · Jan 1990
Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans.
The purpose of this study was to characterize the pharmacodynamics and pharmacokinetics of three concentrations of the new long-acting amide local anesthetic, ropivacaine, given epidurally in 15 physical status ASA I or II patients for elective lower-extremity orthopedic procedures using a nonrandomized open-label design. Three groups of five patients each received either 0.5%, 0.75%, or 1.0% ropivacaine. Upper and lower levels of analgesia to pinprick were determined at frequent intervals until normal sensation had completely returned. ⋯ No statistically significant differences were noted between the three groups in terms of clearance (CL). The mean residence time (MRT) was significantly longer for the 0.5% group when compared with the 1% group. The peak concentration (Cmax) for the 0.5% group was found to be significantly lower than for either the 0.75% or 1% groups.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthesia and analgesia · Jan 1990
Editorial CommentWaking up to desflurane: the anesthetic for the '90s?