Anesthesia and analgesia
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Anesthesia and analgesia · Apr 1993
Randomized Controlled Trial Clinical TrialProphylactic nitroglycerin infusion during noncardiac surgery does not reduce perioperative ischemia.
We evaluated the impact of prophylactic nitroglycerin on the incidence of perioperative myocardial ischemia in patients with known or suspected coronary artery disease who undergo noncardiac surgery. Our goals were to better define the role of nitroglycerin in the management of high-risk patients and to explore the mechanisms of perioperative myocardial ischemia. Patients were assigned randomly to either a control group (n = 23) or to receive 0.9 micrograms.kg-1.min-1 of intravenous nitroglycerin (n = 22). ⋯ The heart rate associated with the onset of ischemia was greater in the nitroglycerin-treated patients than in the control group. We also found that the occurrence of myocardial ischemia on a preoperative Holter recording was strongly predictive of the subsequent occurrence of perioperative ischemia. In conclusion, the addition of nitroglycerin to standard anesthetic management of these high-risk patients does not measurably reduce perioperative ischemia.
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Anesthesia and analgesia · Apr 1993
Comment Letter Comparative StudyORG 9426, succinylcholine or vecuronium: which agent provides "overall superiority" for short outpatient procedures.
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Anesthesia and analgesia · Apr 1993
Case Reports Comparative StudyComplete airway obstruction during arthroscopic shoulder surgery.