Anesthesia and analgesia
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Anesthesia and analgesia · Feb 1995
Meta AnalysisNeurolytic celiac plexus block for treatment of cancer pain: a meta-analysis.
We performed a meta-analysis of the efficacy and safety of neurolytic celiac plexus block (NCPB) for cancer pain. A literature search yielded 59 papers, but data on NCPB in two or more patients was available in only 24 papers. Twenty-one studies were retrospective, one was prospective, and two were randomized and controlled. ⋯ Patients with pancreatic cancer responded similarly to those with other intraabdominal malignancies. Common adverse effects were transient, including local pain (96%), diarrhea (44%), and hypotension (38%); complications occurred in 2%. This analysis suggests that: 1) NCPB has long-lasting benefit for 70%-90% of patients with pancreatic and other intraabdominal cancers, regardless of the technique used; 2) adverse effects are common but transient and mild; and 3) severe adverse effects are uncommon.
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Anesthesia and analgesia · Feb 1995
Randomized Controlled Trial Clinical TrialThe influence of the duration of control stimulation on the onset and recovery of neuromuscular block.
The onset of action of atracurium 450 micrograms/kg, mivacurium 160 micrograms/kg, and vecuronium 80 micrograms/kg was measured after train-of-four (TOF) stimulation had been applied for 1, 5, 10, 15, or 20 min in groups of 10 patients each during anesthesia with thiopental, nitrous oxide-oxygen, and fentanyl. TOF stimulation was applied to the ulnar nerve at 2 Hz every 12 s and the force of contraction of the adductor pollicis muscle recorded. There was a progressive and significant reduction in the time to onset of maximum block with increasing times of control stimulation with all three relaxants (P < 0.0001). ⋯ The time to recovery of T1 (first response in the TOF stimulation) to 25% of control (duration of clinical relaxation) increased from 33 +/- 5.7 to 52 +/- 13.4 min with atracurium, 25 +/- 7.6 to 38 +/- 9.4 min with vecuronium, and 13 +/- 2.5 to 18 +/- 3.5 min with mivacurium with the period of control stimulation increasing from 1 to 20 min. The differences were significant for atracurium and vecuronium (P < 0.05-0.0001). We conclude that increasing periods of control stimulation are associated with decreasing time to onset of neuromuscular block with atracurium, vecuronium, and mivacurium at the adductor pollicis muscle.(ABSTRACT TRUNCATED AT 250 WORDS)