Anesthesia and analgesia
-
Anesthesia and analgesia · Mar 2006
Comparative StudyDeterminants of volatile general anesthetic potency: a preliminary three-dimensional pharmacophore for halogenated anesthetics.
We investigated the molecular basis for the immobilizing activity of halogenated volatile anesthetics using comparative molecular field analysis. In vivo potency data (expressed as minimum alveolar concentrations) for 69 structurally diverse anesthetics were obtained from the literature. The drugs were randomly divided into a training set (n = 52) used to derive the activity model and a test set (n = 17) used to independently assess the model's predictive power. ⋯ The final model explained 94.2% of the variance in the observed activities of the training set compounds. The model showed good predictive capability for both the training set (cross-validated r2 = 0.705) and randomly excluded test set anesthetics (r2 = 0.837). Three-dimensional pharmacophoric maps were derived to identify the spatial distribution of key areas where steric and electrostatic interactions are important in determining immobilizing activity of the halogenated drugs and were compared with our previously published maps obtained for nonhalogenated volatile anesthetics.
-
Anesthesia and analgesia · Mar 2006
Case ReportsVentilatory support using bilevel positive airway pressure during neuraxial blockade in a patient with severe respiratory compromise.
In pregnant patients with myasthenia gravis and respiratory compromise, neuraxial anesthesia for lower abdominal surgery can risk further respiratory depression. We report the use of epidural anesthesia for dilation and curettage and tubal ligation in a 26-yr-old woman with a 12-wk intrauterine pregnancy with severe myasthenia gravis and respiratory insufficiency in whom ventilatory support during anesthesia was provided successfully using bilevel positive airway pressure ventilation. This report demonstrates how the use of bilevel positive airway pressure for ventilatory support may improve the safety of regional anesthesia in patients with severe respiratory compromise.