Anesthesia and analgesia
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Anesthesia and analgesia · Sep 2006
ReviewThe effect of intraperitoneal local anesthesia in laparoscopic cholecystectomy: a systematic review and meta-analysis.
Intraperitoneal administration of local anesthesia is often used to improve pain relief after laparoscopic cholecystectomy. We have conducted a meta-analysis to establish the efficacy of this technique in reducing early postoperative abdominal pain. A systematic literature search revealed 24 randomized, controlled trials assessing intraperitoneal local anesthetic use in laparoscopic cholecystectomy that met inclusion criteria. ⋯ Subgroup analysis suggested that the effect was greater when the local anesthetic was given at the start of the operation (WMD, -13 mm; 95% CI, -19 to -7) compared with instillation at the end (WMD, -6 mm; 95% CI, -10 to -2). No adverse events related to local anesthetic toxicity were reported. We conclude that the use of intraperitoneal local anesthesia is safe, and it results in a statistically significant reduction in early postoperative abdominal pain.
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Anesthesia and analgesia · Sep 2006
Randomized Controlled TrialThe analgesic effects of capsicum plaster at the Zusanli point after abdominal hysterectomy.
Acupuncture has been used to supplement opioid analgesics for postoperative pain control. We designed this double-blind, sham-controlled study to assess the effectiveness of capsicum plaster (PAS) at Zusanli (ST-36) acupoints on postoperative opioid analgesic requirement, side effects, and recovery profile. ⋯ PAS at Zusanli points decreased the postoperative opioid requirement and opioid-related side effects of patients undergoing abdominal hysterectomy.
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Anesthesia and analgesia · Sep 2006
Randomized Controlled TrialPreincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
We reported earlier that preincisional paravertebral block (PVB) provides significant immediate postoperative analgesia after breast cancer surgery. In the same patients (n = 60), a 1-yr follow-up was performed to find out whether PVB could also reduce the prevalence of postoperative chronic pain. The follow-up consisted of a 14-day symptom diary and telephone interviews 1, 6, and 12 mo after surgery. ⋯ These findings were independent of whether or not axillary dissection had been performed. The incidence of neuropathic pain was low (two and three patients in the PVB and control groups, respectively). In addition to providing acute postoperative pain relief, preoperative PVB seems to reduce the prevalence of chronic pain 1 yr after breast cancer surgery.
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Anesthesia and analgesia · Sep 2006
The National Practitioner Data Bank and anesthesia malpractice payments.
A publicly available SPSS database was obtained at the National Practitioner Data Bank website (www.npdb-hipdb.com). After analysis, we found that between 1991 and 2004, there were 276,274 medical malpractice-related payments in the United States. ⋯ Also, the median anesthesia malpractice payments, adjusted to 2005 dollars, increased significantly from 1991 to 1994 and 2001 to 2004 (69,330 dollars versus 205,222 dollars). We conclude that over the past 14 yr, whereas the number of anesthesia malpractice payments has decreased, the median payment of cases has increased.
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5-HT3 receptors are ligand-gated ion channels that are involved in the modulation of emesis and pain. In this study, we investigated whether the opioid analgesic, morphine, exerts specific effects on human 5-HT3 receptors. Whole-cell patches from HEK-293 cells stably transfected with the human 5-HT3A receptor cDNA were used to determine the effects of morphine on the 5-HT-induced currents using the patch clamp technique. ⋯ The morphine antagonist, naloxone, also inhibited 5-HT-induced currents (e.g., at 3 microM by 17%). The effects of morphine and naloxone were not additive. The potency of morphine and the competitivity of the blocking effect points to a specific mechanism at a receptor site rather than an unspecific membrane effect.