Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2007
Multicenter Study Comparative Study Clinical TrialThe safety and efficacy of extended thromboprophylaxis with fondaparinux after major orthopedic surgery of the lower limb with or without a neuraxial or deep peripheral nerve catheter: the EXPERT Study.
The benefit-risk ratio of extended fondaparinux therapy has not been assessed in patients undergoing major lower limb joint arthroplasty. Few data on the concomitant use of fondaparinux and continuous neuraxial or deep peripheral nerve blockade are available. We performed a prospective intervention study in patients undergoing major orthopedic surgery primarily designed to assess the efficacy of fondaparinux when drug administration was withheld for 48 h to permit removal of a neuraxial or deep peripheral nerve catheter. The safety and efficacy of extended fondaparinux therapy for the prevention of venous thromboembolism were also evaluated. ⋯ Once-daily subcutaneous injection of 2.5 mg fondaparinux given for 3 to 5 wk was effective and safe for prevention of venous thromboembolism after major orthopedic surgery. Temporary discontinuation of fondaparinux for 48 h permitted safe removal of a neuraxial or deep peripheral nerve catheter without decreasing thromboprophylatic efficacy.
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Anesthesia and analgesia · Dec 2007
GuidelineSociety for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting.
The present guidelines were compiled by a multidisciplinary international panel of individuals with interest and expertise in postoperative nausea and vomiting (PONV) under the auspices of The Society of Ambulatory Anesthesia. The panel critically evaluated the current medical literature on PONV to provide an evidence-based reference tool for the management of adults and children who are undergoing surgery and are at increased risk for PONV. In brief, these guidelines identify risk factors for PONV in adults and children; recommend approaches for reducing baseline risks for PONV; identify the most effective antiemetic monotherapy and combination therapy regimens for PONV prophylaxis; recommend approaches for treatment of PONV when it occurs; and provide an algorithm for the management of individuals at increased risk for PONV.
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Anesthesia and analgesia · Dec 2007
Comparative StudyA bibliometric analysis of global clinical research by anesthesia departments.
Few studies have investigated the diversity in research conducted by anesthesia-based researchers. We examined global clinical research attributed to anesthesia departments using Medline and Ovid databases. We also investigated the impact of economic development on national academic productivity. ⋯ Clinical research attributable to investigators in our specialty is diverse, and extends beyond the traditional field of anesthesia and intensive care. The United States produces the most clinical research, but per capita output is higher in European nations.
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Anesthesia and analgesia · Dec 2007
ReviewMaximizing the laboratory setting for testing devices and understanding statistical output in pulse oximetry.
Maximizing the laboratory setting for testing baseline pulse oximetry accuracy in an arterial desaturation study requires a study design that considers management of several aspects in the physiology of the test subject, special attention to the device under test, and great care in the preanalytical (sample handling) and analytical (Co-oximeter) phases. Statistics used to describe the resulting SpO2 performance include Precision (size of the data cloud), Bias (offset of the data cloud), and A(rms) (accuracy root mean square), which combines the size and offset of the data cloud in one number. The A(rms) is the primary statistic required by regulatory organizations to describe general performance over the entire saturation range. ⋯ The A(rms) statistic does not have the capacity to represent all pulse oximeter behavior. Saturation pop-ups, drop-downs, frozen readings, and periods of no reading are not portrayed by the A(rms). The next steps in the advancement of regulatory validation testing would be to develop standards that include an expanded analysis of pulse oximeter performance by assessment of pop-ups, dropouts, frozen readings, and periods of no reading through assessment of sensitivity/specificity and possibly a "Performance Index" similar to the approach taken by Barker.
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Anesthesia and analgesia · Dec 2007
Comparative StudyAn experimental and clinical evaluation of a novel central venous catheter with integrated oximetry for pediatric patients undergoing cardiac surgery.
Central venous oxygen saturation (ScvO2) accurately reflects cardiocirculatory function, but is not always feasible in pediatric patients. Using an experimental and clinical approach, we determined the accuracy of a novel pediatric central venous catheter with integrated fiberoptic oximetry, correlated ScvO2 to periprocedural vital variables, and tested its feasibility in pediatric cardiac surgery patients. ⋯ Integrated central venous oximetry catheters provide accurate continuous ScvO2 monitoring in pediatric patients undergoing cardiac surgery. ScvO2 fiberoptic oximetry correlates better with changes in CI as compared to routine hemodynamic variables.