Anesthesia and analgesia
-
Anesthesia and analgesia · Jul 2008
Editorial CommentResidual neuromuscular block: rediscovering the obvious.
-
Anesthesia and analgesia · Jul 2008
Randomized Controlled Trial Comparative StudyEpidural volume extension and intrathecal dose requirement: plain versus hyperbaric bupivacaine.
Epidural volume extension leads to an increase in sensory spread of local anesthetic, but whether this translates into lower dose requirements during combined spinal epidural (CSE) remains undetermined. Likewise, the influence of intrathecal drug baricity on the dose-sparing effect of epidural volume extension has not been investigated. We studied the dose-sparing effect of epidural volume extension and its relation to intrathecal drug baricity by comparing the ED(50) of plain and hyperbaric bupivacaine with and without epidural volume extension. ⋯ Administered with or without epidural volume extension, plain bupivacaine appears to be more effective, requiring a smaller dose and producing a higher sensory block with an earlier onset in comparison to hyperbaric bupivacaine. Epidural volume extension, when applied to intrathecal hyperbaric bupivacaine, fails to decrease the dose or raise the level of block.
-
Anesthesia and analgesia · Jul 2008
Randomized Controlled TrialTreatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial.
Acute postoperative hypertension is a well-known complication of cardiac surgery and is associated with postoperative morbidity. Clevidipine, an ultrashort-acting, third-generation dihydropyridine calcium channel blocker, exerts vascular-selective, arterial-specific vasodilation to decrease arterial blood pressure without negatively impacting cardiac function. In this double-blind, placebo-controlled trial, we examined the efficacy and safety of clevidipine in treating postoperative hypertension in cardiac surgery patients. ⋯ Clevidipine is effective and safe in the rapid treatment of acute postoperative hypertension after cardiac surgery.
-
Anesthesia and analgesia · Jul 2008
Randomized Controlled Trial Comparative StudyA comparison of glidescope videolaryngoscopy to direct laryngoscopy for nasotracheal intubation.
In this study, we compared the effectiveness of direct laryngoscopy (DL) and the GlideScope videolaryngoscope (GVL) for nasotracheal intubation, as judged by the time to intubation (TTI-the primary outcome) and the ease of intubation. ⋯ Compared with DL, the GVL has superior performance characteristics when used for nasotracheal intubation and demonstrates an important reduction of postoperative sore throat. The GVL has a clear role in routine nasotracheal intubation.