Anesthesia and analgesia
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Anesthesia and analgesia · Oct 2009
Case ReportsDelayed quadriparesis after an interscalene brachial plexus block and general anesthesia: a differential diagnosis.
Interscalene brachial plexus block has been widely used for upper limb surgery. Different neurological complications related to this technique have been published. ⋯ Central progression of an interscalene block can produce acute or subacute quadriparesis depending on technical factors of the placement of the local anesthetic and its subsequent spread. The symptomatology and the imaging enabled us to refine the differential diagnoses and to exclude other causes of neurologic compromise.
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Anesthesia and analgesia · Oct 2009
Forecasting and perception of average and latest hours worked by on-call anesthesiologists.
We studied the value of providing information to anesthesia providers about the length of time typically worked during on-call shifts. The mean time at which a shift ends can be used for purposes of trades, payments, or reverse auctions, because the mean is proportional to the total time. The 80th percentile (with a suitable upper confidence limit for uncertainty due to limited sample sizes) can be used for judging the earliest time by which after-work activities reasonably can be planned. ⋯ Historical data from OR or anesthesia information management systems, or from anesthesia billing systems, can be used months before staff scheduling to provide insight to anesthesia providers on respective calls. The data are useful because experience provides limited intuition. Updates on scheduled workload available closer to the day of surgery provided only marginal increases in knowledge over the use of historical data.
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Anesthesia and analgesia · Oct 2009
Case ReportsNovel variants near the central domain of RYR1 in two malignant hyperthermia-susceptible families from Taiwan.
Our primary objective was to detect malignant hyperthermia (MH)-susceptible persons and thereby prevent MH episodes. We identified variants in the ryanodine receptor isoform 1 using molecular pedigree analysis. ⋯ Three novel ryanodine receptor isoform 1 variants located either near or within the central domain might predispose carriers to MH.
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The purpose of this investigation was to identify what perioperative information children want to receive from the medical staff. ⋯ We conclude that the majority of children aged 7-17 yr who undergo surgery want to be given comprehensive perioperative information and health care providers should ensure adequate information regarding postoperative pain is provided.
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Anesthesia and analgesia · Oct 2009
Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.
The mitogen-activated protein kinase family plays an important role in several types of pain. However, the detailed role of phosphorylated extracellular signal-regulated kinase (pERK) in the region of injured peripheral nerve is poorly understood. In this study, we investigated whether pERK in injured sciatic nerve contributes to neuropathic pain induced by partial sciatic nerve ligation (PSL) in mice. ⋯ Activation of ERK in Schwann cells of the injured peripheral nervous system may play an important role in the development of neuropathic pain. Our results suggest that pERK itself and ERK-related mediators are potential therapeutic targets for the treatment of neuropathic pain.