Anesthesia and analgesia
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Anesthesia and analgesia · Jan 2010
Randomized Controlled TrialPerioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial.
Despite the enormous success of total knee arthroplasty (TKA), chronic neuropathic pain can develop postoperatively and is both distressing and difficult to treat once established. We hypothesized that perioperative treatment with pregabalin, a chronic pain medication, would reduce the incidence of postsurgical neuropathic pain. ⋯ Perioperative pregabalin administration reduces the incidence of chronic neuropathic pain after TKA, with less opioid consumption and better range of motion during the first 30 days of rehabilitation. However, in the doses tested, it is associated with a higher risk of early postoperative sedation and confusion.
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Anesthesia and analgesia · Jan 2010
Randomized Controlled TrialHemispheric synchronized sounds and perioperative analgesic requirements.
Data on the effect of Hemisync sounds on perioperative analgesic requirements are scant. ⋯ The use of Hemisync sounds before and during general anesthesia reduces intraoperative analgesic requirements, postoperative pain scores, and discharge time.
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Anesthesia and analgesia · Jan 2010
Randomized Controlled TrialA randomized, double-blind, placebo-controlled trial of epidural morphine analgesia after vaginal delivery.
Pain after vaginal delivery can interfere with the activities of daily living. We hypothesized that epidural medication administered after delivery would be of benefit for acute postpartum pain management. The objective of this study was to assess whether epidural morphine after vaginal delivery would reduce the analgesic requirements for perineal pain. ⋯ There was a 78% reduction in analgesic requirements in women given epidural morphine after vaginal delivery compared with placebo for both primiparous and multiparous patients. Women who receive epidural labor analgesia for vaginal deliveries and stay in the hospital for 24 h after delivery may benefit from postpartum administration of epidural morphine.
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Anesthesia and analgesia · Jan 2010
Randomized Controlled TrialThe GlideScope facilitates nasogastric tube insertion: a randomized clinical trial.
The GlideScope (Saturn Biomedical Systems, B.C., Canada) is a reusable videolaryngoscope and is considered an effective device for tracheal intubation. We designed this study to evaluate the application of this device in nasogastric tube (NGT) insertion. ⋯ GlideScope facilitates NGT insertion and reduces the duration of the procedure.
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Anesthesia and analgesia · Jan 2010
Comparative StudyThe risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery.
Aprotinin is superior to other antifibrinolytic drugs for preventing major blood loss after cardiac surgery but may also increase perioperative mortality. It remains unclear whether its risk-benefit profile differs among low-, moderate-, and high-risk cardiac surgical patients. ⋯ Aprotinin tends to have a better risk-benefit profile than tranexamic acid in high-risk, but not low- to moderate-risk, patients. Its use in high-risk cases may therefore be warranted.