Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2011
Comparative StudyKnockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in rats.
Previous studies have demonstrated that Homer 1b/c, a postsynaptic molecular scaffolding protein that binds and clusters metabotropic glutamate receptors at neuronal synapses, has an important role in the metabotropic glutamate receptor signaling process. In the current study, we investigated the possible involvement of Homer 1b/c in secondary hyperalgesia induced by complete Freund's adjuvant (CFA). ⋯ These novel results demonstrate that Homer 1b/c in the spinal cord contributes to the maintenance of secondary hyperalgesia induced by CFA and suggest that Homer 1b/c may be a novel target for pain therapy.
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Anesthesia and analgesia · Dec 2011
Comparative StudyInhibition of KCC2 in mouse spinal cord neurons leads to hypersensitivity to thermal stimulation.
KCC2, a neuronal-specific K-Cl cotransporter, is involved in pain perception physiology through its effects on postsynaptic inhibition in spinal cord neurons. We injected a newly identified, highly potent and selective inhibitor of KCC2 (D4), an inactive structural variant (D4.14), and the Na-K-2Cl cotransporter (NKCC1) inhibitor, bumetanide, into the intrathecal space of mice to measure their effect on heat-evoked nociceptive responses. ⋯ Inhibition of KCC2 by D4 led to decreased heat-evoked withdrawal latency in mice, as measured by hotplate and tail flick assays, whereas inhibition of NKCC1 by bumetanide resulted in increased response latencies to heat stimuli as measured by both of these nociceptive tests.
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Anesthesia and analgesia · Dec 2011
Comparative StudyAutomatic computerized endotracheal tube position verification: an animal model evaluation.
Improper endotracheal tube positioning carries a high risk for morbidity and mortality; verification and confirmation of correct placement is necessary. We propose a computer-automated identification of endotracheal tube positioning using image analysis. The end product will not retain a monitor; rather, the acquired image will be automatically analyzed by a mini electronic processor. ⋯ A potential tube position verification system was assessed. High accuracy of the analysis algorithm was shown using nonperfused biological tissue, justifying further research.
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Anesthesia and analgesia · Dec 2011
Case ReportsHigh thoracic/cervical epidural blood patch for spontaneous cerebrospinal fluid leak: a new challenge for anesthesiologists.
Spontaneous cerebral spinal fluid leakage is increasingly recognized as a cause of headache due to low intracranial pressure. The site of leakage can be identified with radionuclide cisternography, and anesthesiologists are increasingly requested to provide epidural blood patch for their management. This series of case reports demonstrates some of the issues relating to the management of this condition.
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Anesthesia and analgesia · Dec 2011
What's new in obstetric anesthesia? The 2011 Gerard W. Ostheimer Lecture.
The "What's New in Obstetric Anesthesia" lecture was established by the Society for Obstetric Anesthesia and Perinatology in 1975 to update members on the preceding year's medical literature. In 1995, the lecture was renamed in honor of Gerard W. ⋯ The Ostheimer lecturer reviews the obstetric anesthesia, obstetric, perinatology, and health services literature to identify articles that are relevant to the practice of obstetric anesthesiology. This review summarizes the most relevant publications from the 2010 literature.