Anesthesia and analgesia
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Anesthesia and analgesia · May 2011
Volatile anesthetics may not induce significant toxicity to human neuron-like cells.
In vitro experiments and in vivo animal studies suggest detrimental effects of volatile anesthetics including isoflurane on brain cells. It is not clear whether volatile anesthetics can cause human brain cell injury. ⋯ Our results suggest that volatile anesthetics at clinically relevant concentrations do not cause human neuron-like cell injury. Isoflurane also may not alter the quantity of dendritic spines and synapses in these human cells.