Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2012
Paracetamol does not compromise early wound repair in the intestine or abdominal wall in the rat.
Paracetamol is a cornerstone for perioperative pain relief. Its mechanism of action may include a local anti-inflammatory effect with inhibition of cyclooxygenase isoenzymes. The scarce literature available on its effects on wound healing consists of preclinical studies into the effect of paracetamol on healing of the musculoskeletal system. Although the drug is used abundantly for pain relief after surgery of the gastrointestinal tract, there are no published data on the influence of paracetamol on anastomotic and abdominal healing. This also holds for the crucial, early inflammatory phase of repair. The recovery of wound strength could therefore conceivably be affected by paracetamol. ⋯ Perioperative use of paracetamol in a rat model of intestinal surgery does not significantly impede wound repair in the early postoperative period.
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Anesthesia and analgesia · Dec 2012
Biography Historical ArticleSpecial article: Nicholas M. Greene: visionary educator, clinician, editor, and humanitarian.