Anesthesia and analgesia
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Anesthesia and analgesia · Jan 2013
Randomized Controlled TrialTransport decreases the quality of cardiopulmonary resuscitation during simulated maternal cardiac arrest.
The purpose of this study was to compare cardiopulmonary resuscitation (CPR) for simulated maternal cardiac arrest rendered during transport to the operating room with that rendered while stationary in the labor room. We hypothesized that the quality of CPR would deteriorate during transport. ⋯ Our data confirm our hypothesis and demonstrate that transport negatively affects the overall quality of resuscitation on a mannequin during simulated maternal arrest. These findings, together with previously published data on transport-related delays when moving from the labor room to the operating room further strengthen recommendations that perimortem cesarean delivery should be performed at the site of maternal cardiac arrest.
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Anesthesia and analgesia · Jan 2013
Comparative StudyThe impact of multilumen infusion devices on the occurrence of known physical drug incompatibility: a controlled in vitro study.
Drug incompatibility is a problem, especially when managing patients in intensive care units. We designed the present study to assess the impact of multilumen infusion access devices on the occurrence of known physical drug incompatibility through a controlled in vitro study. ⋯ Infusion device characteristics appear to have an impact on the physical compatibility of the 2 drugs. Under specified conditions, the 9-lumen infusion access device prevents physical furosemide-midazolam incompatibility.
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Anesthesia and analgesia · Jan 2013
First evidence of a polygenic susceptibility to pain in a pediatric cohort.
There is currently no evidence about the genetic bases of postoperative pain variability in children. ⋯ ABCB1 and OPRM genotypes are associated with clinically meaningful pain variability, whereas NTRK1 and COMT are linked to subclinical effects. This first but small cohort study provides clues to further explore the genetic foundations of pediatric pain.
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Anesthesia and analgesia · Jan 2013
An observational study of the fresh frozen plasma: red blood cell ratio in postpartum hemorrhage.
Postpartum hemorrhage is the leading cause of maternal death worldwide. Recent data from trauma patients and patients with hemorrhagic shock have suggested that an increased fresh frozen plasma:red blood cell (FFP:RBC) ratio may be of benefit in massive bleeding. We addressed this issue in cases of severe postpartum hemorrhage. ⋯ In this retrospective study, a higher FFP:RBC ratio was associated with a lower requirement for advanced interventional procedures in the setting of postpartum hemorrhage. The benefits of transfusion using a higher FFP:RBC ratio should be confirmed by randomized-controlled trials.