Anesthesia and analgesia
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Anesthesia and analgesia · Nov 2021
The Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines.
The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. We examined the relationship between the antinociceptive effect and the expression level of programmed cell death ligand-1 (PD-L1) during pregnancy and further observed the changes in pain thresholds and expression levels of cytokines in late-pregnant mice before and after blockade of PD-L1 or programmed cell death-1 (PD-1). ⋯ The PD-L1/PD-1 pathway mediates pregnancy-induced analgesia, partially via the regulation of cytokines.
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Anesthesia and analgesia · Nov 2021
Editorial CommentGabapentinoids: When Is the Right Moment to Stop?