Anesthesia and analgesia
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Anesthesia and analgesia · Apr 1997
Nalbuphine coadministered with morphine prevents tolerance and dependence.
Nalbuphine, an opioid mixed agonist-antagonist, prevents many morphine-related side effects. In this study, we compared the effects of nalbuphine versus naloxone on the prevention of morphine tolerance and dependence in Sprague-Dawley rats. Group 1 received a morphine 5 mg/kg intraperitoneal (I. ⋯ P.). We found that coadministration of nalbuphine or naloxone with morphine dose-dependently blocked the development of morphine tolerance and dependence. However, unlike naloxone, nalbuphine did not attenuate the antinociceptive effect of morphine.
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Anesthesia and analgesia · Apr 1997
Do not resuscitate orders in the perioperative period: patient perspectives.
The purpose of this study was to determine the perspectives and opinions of terminally ill patients regarding the management of their do not resuscitate (DNR) orders in the perioperative period. Eighteen patients who had DNR orders and were willing to discuss those orders and their intentions were identified by hospital nurses or hospice workers. An in-depth interview was conducted with each patient. ⋯ Others were satisfied with discussing the intent of their orders. For various reasons and for various procedures, many patients with DNR orders are willing to undergo anesthesia and surgery. Anesthesiologists' awareness of the variety of opinions and perspectives held by patients regarding their DNR orders will enhance their preoperative discussion.
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Anesthesia and analgesia · Apr 1997
Comment Letter Comparative StudyProphylactic antiemetics for laparoscopic cholecystectomy: ondansetron versus droperidol plus metoclopramide.