Anesthesia and analgesia
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Anesthesia and analgesia · May 1989
Sufentanil does not block sympathetic responses to surgical stimuli in patients having coronary artery revascularization surgery.
The effects of a moderate dose of sufentanil (1 microgram.kg-1 + 0.015 micrograms.kg-1.min-1) plus nitrous oxide (30% O2/70% N2O) anesthesia (group I; n = 8) and of high-dose sufentanil/O2 anesthesia (10 micrograms.kg-1 + 0.15 micrograms.kg-1.min-1) without N2O (group II; n = 8) on cardiovascular dynamics, myocardial blood flow, myocardial oxygen consumption, myocardial lactate balance, and hypoxanthine release were studied in two groups of male patients scheduled for elective coronary artery bypass surgery. All patients were on maintenance doses of calcium channel blockers and nitrates with the last doses of medications given the morning of operation. All patients were premedicated with flunitrazepam (2 mg orally), piritramide (7.5 mg IM) and promethazine (25 mg IM). ⋯ Following the induction myocardial blood flow and myocardial oxygen consumption decreased 23% (79 ml.min-1.100 g-1 to 61 ml.min-1.100 g-1 and 28% (9.2 ml O2.min-1.100 g-1 to 6.6 ml O2.min-1.100 g-1) in group I and 14% (78 ml.min-1.100 g-1 to 67 ml.min-1.100 g-1 and 18% (8.7 ml O2.min-1.100 g-1 to 7.1 ml O2.min-1.100 g-1) in group II. Myocardial ischemia was seen in one patient of group II (patient No. 4), as indicated by a hypoxanthine release into the coronary sinus, when after the induction MAP decreased from 93 to 67 mm Hg and heart rate increased from 56 to 71 min-1. During sternotomy 8 of 16 patients (50%) developed hypertension and 9 of 16 patients (56%) showed signs of myocardial ischemia, i.e., a lactate and hypoxanthine release.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthesia and analgesia · May 1989
Randomized Controlled Trial Clinical TrialTime course and hemodynamic effects of alpha-1-adrenergic bolus administration in anesthetized patients with myocardial disease.
Phenylephrine (Phe) is frequently administered as an intravenous (IV) bolus to increase blood pressure, yet the acute time course and hemodynamic effects of bolus Phe in patients with myocardial disease have not been reported. Therefore 50 randomized IV bolus doses of Phe (50, 100, 150, or 200 micrograms) were given to 18 patients during anesthesia for elective coronary artery surgery. Esophageal Doppler techniques were used to continuously monitor cardiac output (CO); mean arterial pressure (MAP), CO, and calculated systemic vascular resistance (SVR) were recorded every 5 seconds for a total of 2 minutes. ⋯ They consisted of an increase in MAP (11.6 +/- 2.1, 15.6 +/- 2.4, 14.7 +/- 2.4, 18.0 +/- 1.5 mm Hg); increase in SVR (766 +/- 190, 930 +/- 310, 950 +/- 344, 1732 +/- 824 dynes.sec.cm-5); and a decrease in CO (-.58 +/- .11, -.68 +/- .13, -.73 +/- .20, -.77 +/- .18 L.min-1). Hypertension, increased age, low preoperative ejection fraction, high baseline CO, and low baseline SVR significantly (P less than 0.05) decreased hemodynamic responses to Phe (see text). In conclusion, bolus IV Phe in patients with myocardial disease increases MAP and SVR and simultaneously decreases CO; these peak hemodynamic events occur approximately 42 seconds after Phe administration.
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Hospitalization arouses anxiety among patients admitted for day bed surgery. The effect of the anesthetist's routine preoperative interview on the anxiety levels of 63 unpremedicated women scheduled for elective outpatient therapeutic abortions was examined using the State-Trait Anxiety Inventory. The anesthetist's preoperative interviews were performed at the following times: Group 1, in the outpatient clinic one week before surgery; group 2, in the day bed unit at the time of admission to hospital; group 3, outside the operating room immediately prior to surgery. ⋯ State: group 1, 50.6 +/- 3.5; group 2, 43.0 +/- 2.4; group 3, 49.0 +/- 3.0). Only in group 3 did the anesthetist's interview significantly reduce patient's anxiety (before visit 49.1 +/- 3.0; after visit 46.0 +/- 2.8; P less than 0.05). A small but statistically significant reduction in State anxiety scores is achieved when patients are seen by the anesthetist immediately prior to surgery.
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Anesthesia and analgesia · Apr 1989
Needle direction affects the sensory level of spinal anesthesia.
The effect of the direction of the spinal needle on the sensory level of anesthesia was investigated. Three ml plain bupivacaine 0.5%, previously equilibrated to 37 degrees C, were injected intrathecally in two groups of twenty patients, who were kept sitting for three minutes after injection. ⋯ The differences between segmental levels of sensory loss between groups 1 and 2 (T 3.4 and T 5.1, respectively) and of temperature loss (T 2.6 and T 4.2, respectively) 30 minutes after injection of bupivacaine were statistically significant. It is concluded that a steep paramedian approach of the subarachnoid space with an angle of less than 50 degrees results in a cephalad spread averaging about 1.6 segments greater than when the needle is in the perpendicular position.