Anesthesia and analgesia
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Anesthesia and analgesia · Apr 1989
Historical ArticleFifty-eight years ago in Anesthesia & Analgesia. B. Bolliger, K. Maddox: Experimental anesthesia with tri-bromethyl alcohol (Avertin) and sodium iso-amyl-ethyl-barbiturate (Amytal). Current Researches in Anesthesia and Analgesia: 1931; 10:112-115.
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Anesthesia and analgesia · Mar 1989
Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats.
It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. ⋯ MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics.
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Anesthesia and analgesia · Mar 1989
Randomized Controlled Trial Clinical TrialEpidural hydromorphone with and without epinephrine for post-operative analgesia after cesarean delivery.
The efficacy of epidural hydromorphone alone or in combination with epinephrine for postoperative analgesia was evaluated in 30 healthy women who underwent cesarean delivery with epidural anesthesia. They were assigned randomly to receive either 1.5 mg hydromorphone alone (N = 15) or 1.5 mg hydromorphone with 1/200,000 epinephrine (N = 15). Duration of analgesia (mean +/- SD) was 24.3 +/- 9.4 hours after the epidural injection of hydromorphone plus epinephrine. ⋯ Side effects including pruritus (73%), nausea (20%), and vomiting (15%) were of similar frequency with and without epinephrine. Although mean venous PCO2 (PvCO2) levels three and six hours after the hydromorphone-epinephrine dose were elevated significantly over the pre-drug PvCO2 levels, no respiratory depression was detected by an apnea monitor to which all patients were connected. The addition of epinephrine to epidural hydromorphone hastened onset and prolonged the duration of analgesia after cesarean section.