Headache
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Multicenter Study Clinical Trial
Nefazodone for chronic daily headache prophylaxis: an open-label study.
To assess effectiveness, tolerability, and safety of nefazodone as a prophylactic agent for chronic daily headache. ⋯ These results provide preliminary support for the efficacy of nefazodone in the prophylaxis of chronic daily headache. In this sample, nefazodone was safe and generally well tolerated. Patient ratings of sexual function improved over the course of treatment, in contrast to what is generally observed with most antidepressants. Nefazodone may be particularly beneficial for patients with chronic daily headache and comorbid depression. Further research is indicated.
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To assess effectiveness and safety of tizanidine hydrochloride tablets for the prophylaxis of chronic daily headache. ⋯ The results provide preliminary support for the efficacy, safety, and tolerability of tizanidine in the prophylaxis of chronic daily headache.
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To evaluate atraumatic spinal needle use among US neurologists. ⋯ Atraumatic spinal needles for lumbar puncture have been shown to dramatically decrease the risk of postdural puncture headache. Although the use of these needles is standard practice among anesthesiologists, they have not been adopted by other medical specialties. This may lead to unnecessary morbidity among patients undergoing lumbar puncture.
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Randomized Controlled Trial Clinical Trial
Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study.
To determine the efficacy of naratriptan 1-mg and 2.5-mg tablets twice daily compared with placebo as short-term prophylaxis of menstrually associated migraine. ⋯ Naratriptan, 1 mg, with tolerability similar to placebo, is an effective, short-term, prophylactic treatment for menstrually associated migraine.