Headache
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Zolmitriptan 5 mg nasal spray: efficacy and onset of action in the acute treatment of migraine--results from phase 1 of the REALIZE Study.
The objective of phase 1 (reported here) of this two-phase study was to assess the efficacy of zolmitriptan 5 mg nasal spray, in terms of ability to provide relief from all migraine symptoms, in a controlled setting, designed to replicate clinical practice. ⋯ These findings confirm the efficacy demonstrated by zolmitriptan nasal spray in previous clinical trials.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks.
The study compared efficacy and tolerability of intravenous valproate (iVPA) with intravenous lysine-acetylsalicylic acid (iLAS) in acute migraine attacks. Background.-iLAS has been proven to be a highly effective treatment in acute migraine attacks, but it is not available in many countries and contraindicated in patients with asthma or peptic ulcers. Current data suggest that iVPA may be effective in the treatment of acute migraine attacks. ⋯ Both drugs were effective in acute migraine attacks with a trend in favor of iLAS. As both drugs were well tolerated, further studies with higher doses of iVPA for the treatment of acute migraine attacks are recommended.
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Randomized Controlled Trial Clinical Trial
Dextroamphetamine pilot crossover trials and n of 1 trials in patients with chronic tension-type and migraine headache.
To examine the preventive effects of dextroamphetamine in select small groups of patients with chronic tension-type and migraine headache. ⋯ Dextroamphetamine had real preventive effects on chronic tension-type and migraine headaches in some subjects. These results should encourage other investigators to study its effects on these headaches.
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Randomized Controlled Trial Comparative Study Clinical Trial
Rizatriptan 5 mg for the acute treatment of migraine in adolescents: results from a double-blind, single-attack study and two open-label, multiple-attack studies.
To examine the short- and long-term efficacy and tolerability of rizatriptan 5 mg in adolescents with migraine. ⋯ Rizatriptan 5 mg was not more effective than placebo in the treatment of a single migraine attack in adolescents, but appeared to be more effective than standard care for treating multiple attacks occurring over 1 year in these patients. Rizatriptan 5 mg was well tolerated in adolescents during short-term and long-term use.
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Randomized Controlled Trial Comparative Study Clinical Trial
A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial.
To determine the efficacy for migraine prophylaxis of a compound containing a combination of riboflavin, magnesium, and feverfew. ⋯ Riboflavin 25 mg showed an effect comparable to a combination of riboflavin 400 mg, magnesium 300 mg, and feverfew 100 mg. The placebo response exceeds that reported for any other placebo in trials of migraine prophylaxis, and suggests that riboflavin 25 mg may be an active comparator. There is at present conflicting scientific evidence with regard to the efficacy of these compounds for migraine prophylaxis.