Headache
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To investigate cervical, interictal reproduction of usual head pain and its effect on the nociceptive blink reflex in migraineurs. ⋯ Our findings corroborate previous results related to anatomical and functional convergence of trigeminal and cervical afferent pathways in animals and humans, and suggest that manual cervical modulation of this pathway is of potential benefit in migraine.
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To reinvestigate the innervation pattern of the dura mater of rat and human middle cranial fossa, the morpho-functional substrate of headache generation, and adjacent extracranial tissues with neuronal in vitro tracing. ⋯ We conclude that a proportion of meningeal afferents innervates extracranial tissues like periosteum and pericranial muscles via collaterals projecting through the skull. These afferents may be nociceptive, some may subserve proprioceptive functions. The finding of extracranial projections of meningeal afferents may be important for our understanding of extracranial impacts on headache generation and therapy.
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To identify possible clinical differences between male, premenopausal, and postmenopausal female patients with burning mouth symptoms. ⋯ Male and premenopausal female patients with burning mouth symptoms showed different characteristics compared with typical postmenopausal female patients.
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Refine the classification of migraine subtypes by applying factor mixture models (FMM) to a large population sample of people with headache. ⋯ Statistically based classification using FMM extends traditional clinical syndrome-based diagnosis. FMM can serve as an important tool to parse phenotypic heterogeneity and identify natural migraine subgroups. This approach may improve our ability to diagnosis migraine, to select initial therapy, to predict prognosis, and to discover biomarkers and genes.