Headache
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Recent genome-wide association studies (GWAS) have identified 3 loci in or near PRDM16 (1p36.32, rs2651899), LRP1 (12q13.3, rs11172113) and TRPM8 (2q37.1, rs10166942) in the population-based Women's Genome Health Study (WGHS) of migraine, and 2 loci in or near TRPM8 and LRP1 were repeated in European GWAS study. To evaluate whether the same variants are related to migraine in Chinese population, we investigated migraine with aura (MA) and migraine without aura (MO) patients of Chinese Han ethnicity in mainland China. ⋯ Our data suggested that rs2651899 variant in PRDM16 plays a potential role in Chinese MO migraine susceptibility, and gender may not play a role.
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Comparative Study
Headache diagnoses among Iraq and Afghanistan war veterans enrolled in VA: a gender comparison.
To examine the prevalence and correlates of headache diagnoses, by gender, among Iraq and Afghanistan War Veterans who use Department of Veterans Affairs (VA) health care. ⋯ Results of this study have implications for the delivery of post-deployment health services to Iraq and Afghanistan War Veterans. Migraine and other headache diagnoses are common among Veterans, particularly women, and tend to occur in combination with other post-deployment health conditions for which patients are being treated.
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To determine the impact of post-traumatic stress disorder (PTSD) on headache characteristics and headache prognosis in U.S. soldiers with post-traumatic headache. ⋯ PTSD is prevalent among U.S. Army soldiers with post-traumatic headache. Comorbid PTSD is not associated with more frequent headaches or chronic daily headache in soldiers evaluated at a military neurology clinic for chronic post-traumatic headache. Comorbid PTSD does not adversely affect short-term headache outcomes, although prospective controlled trials are needed to better assess this relationship.
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Genome-wide association studies (GWAS) have identified various migraine susceptibility variants. We aim to replicate 5 GWAS-associated polymorphisms (rs1835740, LRP1 rs11172113, TRPM8 rs10166942, PRDM16 rs2651899, and TGFBR2 rs7640453) in the North Indian population. Furthermore, we checked the single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium (LD) with the selected variants. We also undertook to predict the functional effect (in silico) of the variants. ⋯ We report significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the North Indian population. Finally, we present the first replication study of GWAS-associated polymorphisms in a population other than European.