Gut
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
Proceedings: A controlled comparison of highly selective vagotomy against truncal vagotomy and pyloroplasty for duodenal ulcer.
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Randomized Controlled Trial Clinical Trial
Proceedings: The importance of bacteroides as a cause of severe sepsis after colo-rectal surgery.
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Randomized Controlled Trial Clinical Trial
A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis.
Treatment of the coagulation disturbances developing with hepatic damage following a paracetamol overdose was assessed in a controlled trial of 22 patients, one half being given heparin and fresh frozen plasma and the other fresh frozen plasma alone. No significant difference was observed either in the speed of correction of the coagulation defect or in the clinical outcome. Two-thirds of the patients had evidence of disseminated intravascular coagulation, but despite the presence of a severe coagulation defect, significant bleeding occurred in only five patients. This may be because with paracetamol-induced hepatic necrosis both the coagulation defect (and possibly other features attributable to severe hepatic insufficiency) are of shorter duration than in hepatic necrosis due to causes such as viral hepatitis in which the liver damage may be a continuing process.
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
A comparative study of conventional premedication (pethidine, promethazine, and atropine) and neuroleptanalgesia (droperidol and phenoperidine) for peroral endoscopy.
A double blind comparison of conventional premedication (pethidine, promethazine, and atropine) and neuroleptanalgesia (droperidol and phenoperidine) failed to demonstrate any difference in either the comfort of the patient or ease of instrumentation in 70 upper gastrointestinal tract endoscopies. Further trials are needed before conventional premedication is abandoned.