European journal of clinical investigation
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Eur. J. Clin. Invest. · Feb 2022
Observational StudyAlterations in gut microbiota and elevated serum bilirubin in primary biliary cholangitis patients treated with ursodeoxycholic acid.
The prognosis of primary bile cholangitis (PBC) is linked to gut microbiota dysbiosis. This study investigated the association between the gut microbiome and elevated total bilirubin (TB) level in PBC patients treated with ursodeoxycholic acid (UCDA). ⋯ TB level in PBC patients treated for 12 months with UCDA is associated with a distinct gut microbiome profile.
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Eur. J. Clin. Invest. · Feb 2022
Retinal blood vessel caliber and vascular ageing in a general Spanish population. EVA study.
The aim of this work was to analyse the association of the retinal arteriolar calibre and the arteriole/venule index (AV index) with vascular ageing in a general population without previous cardiovascular disease. ⋯ Lower values of AV index and retinal arteriolar calibre were associated with vascular ageing in a general Spanish population without previous cardiovascular disease.
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Eur. J. Clin. Invest. · Feb 2022
Obesity paradox in patients with chronic total occlusion of coronary artery.
Obesity is associated with metabolic syndrome which increases further risk of coronary artery disease and adverse cardiovascular events. Impact of body mass index (BMI) on long-term outcome in patients with coronary chronic total occlusion (CTO) is less clear. ⋯ Higher BMI was associated with better long-term outcome in patients with coronary CTO.
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Eur. J. Clin. Invest. · Feb 2022
A Score System to Predict No-Reflow in Primary Percutaneous Coronary Intervention: the PIANO Score.
Angiographic no-reflow is associated with poor outcomes in patients with ST-segment elevation myocardial infarction (STEMI). We sought to develop and validate a score system to predict angiographic no-reflow in primary percutaneous coronary intervention (PCI). ⋯ We establish and validate a score system based on six clinical variables to predict angiographic no-reflow in STEMI patients undergoing primary PCI, which may help choose the optimal individual treatment strategy.
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Eur. J. Clin. Invest. · Feb 2022
Clinical investigation of dynamic and enduring aspects of global cognition in aged population.
A major issue in evaluating the cognitive status of ageing populations is a clear distinction between enduring and dynamic aspects of global cognition necessary for evaluating risks of dementia and effectiveness of preventive interventions. ⋯ The MMSE measures both dynamic and enduring cognitive aspects and is suitable for general clinical assessments, while the MMSE-D8 can be used to monitor transitory changes of global cognition over time. The TICS-M is more useful for measuring enduring features of cognition and screening for dementia. Our findings highlight the value of generalizability theory to distinguish dynamic and enduring features of cognition, which may contribute to preventive interventions and monitoring cognitive ability over time.