European journal of clinical investigation
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Eur. J. Clin. Invest. · Feb 2021
Review Meta AnalysisA meta-analysis on the diagnostic performance of magnetic resonance imaging and transient elastography in Nonalcoholic Fatty Liver Disease.
Noninvasive methods have been used for the assessment of hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD). The aim was to assess the efficacy and accuracy of both magnetic resonance imaging(MRI) and transient elastography(TE) for the evaluation of hepatic steatosis. ⋯ MRI-PDFF and TE-CAP both provide highly accurate noninvasive approaches for quantifying and staging hepatic steatosis in NAFLD. Compared with TE-CAP, MRI-PDFF is significantly more accurate for evaluating dichotomized grades of steatosis.
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Eur. J. Clin. Invest. · Feb 2021
Meta AnalysisEffects of antidiabetic drugs on psoriasis: A meta-analysis.
Psoriasis, a chronic inflammatory skin disease, poses an elevated risk of developing diabetes mellitus. ⋯ The current evidence demonstrates therapeutic efficacy of pioglitazone, which may be a treatment option in patients with psoriasis and diabetes mellitus.
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Eur. J. Clin. Invest. · Jan 2021
Review Meta AnalysisDeciphering the COVID-19 cytokine storm: Systematic review and meta-analysis.
The coronavirus pandemic has affected more than 20 million people so far. Elevated cytokines and suppressed immune responses have been hypothesized to set off a cytokine storm, contributing to ARDS, multiple-organ failure and, in the most severe cases, death. We aimed to quantify the differences in the circulating levels of major inflammatory and immunological markers between severe and nonsevere COVID-19 patients. ⋯ Severe COVID-19 is characterized by significantly increased levels of pro-inflammatory cytokines and reduced T lymphocytes. Well-designed and adequately powered prospective studies are needed to amplify the current evidence and provide definitive answers to dilemmas regarding timing and type of anti-COVID-19 therapy particularly in severe patients.
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Eur. J. Clin. Invest. · Jan 2021
Meta AnalysisHigh rates of pulmonary artery occlusions in COVID-19. A meta-analysis.
COVID-19 patients are considered at high risk of venous thromboembolism (VTE). The real nature of pulmonary artery occlusions (PAO) in COVID-19 has been questioned, suggesting that it is caused also by in situ thrombi, rather than only by emboli (PE) from peripheral thrombi. ⋯ The results of our meta-analysis highlight a disproportion in the prevalence of PE among all VTE events in COVID 19 patients, likely reflecting PAO by pulmonary thrombi, rather than emboli from peripheral vein thrombi.
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Eur. J. Clin. Invest. · Jan 2021
Review Meta AnalysisThe impact of chronic obstructive pulmonary disease on hospitalization and mortality in patients with heart failure.
Several studies have suggested that chronic obstructive pulmonary disease (COPD) could be predictive of the prognosis in patients with heart failure (HF), but yield conflicting findings. Therefore, we conducted a meta-analysis to examine the impact of COPD on adverse outcomes in patients with HF. ⋯ COPD comorbidity could increase the risk of all-cause mortality of HF patients. Future research should confirm the findings on hospitalization because of the limited studies included for this outcome.