European journal of clinical investigation
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Eur. J. Clin. Invest. · Dec 2023
Review Meta AnalysisCaveolin-1 protein expression as a prognostic biomarker of gastrointestinal tumours: A systematic review and meta-analysis.
Gastrointestinal (GI) cancers remain a major threat worldwide, accounting for over 30% of cancer deaths. The identification of novel prognostic biomarkers remains a challenge despite significant advances in the field. The CAV1 gene, encoding the caveolin-1 protein, remains enigmatic in cancer and carcinogenesis, as it has been proposed to act as both a tumour promoter and a tumour suppressor. ⋯ The data suggest that caveolin-1 expression in the tumour cells of oesophageal, pancreatic cancer and HCC and in the stroma of colorectal cancer may be an important novel predictive biomarker for the clinical management of these diseases in a curative setting. However, the main conclusion of our analysis is that caveolin-1 expression should always be assessed separately in stroma and tumour cells.
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Eur. J. Clin. Invest. · Nov 2023
Review Meta AnalysisLong-term safety of macitentan in patients with pulmonary hypertension: A meta-analysis of randomised controlled trials.
Macitentan has demonstrated its effectiveness in patients with pulmonary hypertension (PH), but its safety, especially for long-term use, needs to be further explored. This systematic review and meta-analysis aimed to determine the safety of long-term use of macitentan in patients with PH. ⋯ The long-term use of macitentan is safe for patients with PH, although with a higher risk of anaemia, headache and bronchitis.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisReparixin improves survival in critically ill and transplant patients: A meta-analysis.
Reparixin, an anti-inflammatory drug that inhibits interleukin 8 (IL-8) activity, might be life-saving for high-risk in-hospital patients without increasing the risk of infection according to a previous meta-analysis. With the increasing availability of randomised data the aim of the current study is to update previous findings by including any randomised control trials (RCTs) investigating the impact of reparixin on survival of critically ill or transplant patients. ⋯ The findings of this meta-analysis indicate that reparixin, an anti-inflammatory drug, improved survival in critically ill or transplant patients (including both COVID-19 and non-COVID-19 patients) without increasing the risk of infection.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisImpact of vitamin D supplementation on markers of bone turnover: Systematic review and meta-analysis of randomised controlled trials.
The effects of vitamin D administration on bone turnover markers (BTMs) in adults are controversial. Thus, we carried out a meta-analysis of available randomised controlled trials (RCTs) to examine the impact of vitamin D supplementation on BTMs. ⋯ Vitamin D administration decreases DPD, PINP and ALP levels, indicating a reduced bone turnover following the intervention. Other BTMs, for example, CTX or OC values, were not affected by vitamin D prescription. Vitamin D supplementation may exert a positive effect on some important BTMs.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisAssociation of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
This study aimed to systematically evaluate the role of circulating levels of choline and betaine in the risk of cardiovascular disease (CVD) and all-cause mortality by comprehensively reviewing observational studies. ⋯ Higher levels of circulating choline were associated with a higher risk of CVD and all-cause mortality.