Lancet
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Comparative Study
Protective effect of rear-seat restraints during car collisions.
The nature of injuries to 2684 car occupants involved in 1055 car accidents were analysed. Less than 1% front-seat occupants were children, compared with 25% of rear-seat passengers. Nearly all (97%) rear-seat passengers were unrestrained. ⋯ Injury severity distribution was similar for front-seat as for rear-seat occupants. Except for minor-to-moderate neck injuries, which were the result of deceleration, most injuries to rear-seat passengers were due to contact with the front seat, with glazing materials, or with other parts of the car. The use of car restraints by rear-seat passengers should reduce the incidence and severity of injuries.
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Randomized Controlled Trial Clinical Trial
Hypoxic-reperfusion injury in the inflamed human joint.
A series of experiments showed that, on exercise of the inflamed human knee, intra-articular pressure rises above synovial capillary perfusion pressure, causing intra-articular hypoxia; and that, on cessation of exercise, there is oxidative damage to lipids and IgG within the joint. These findings are consistent with the hypothesis that persistence of synovial inflammation can be due to exercise-induced hypoxic-reperfusion injury mediated by reactive oxygen species.