Lancet
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Randomized Controlled Trial Multicenter Study Clinical Trial
Risk, causes, and prevention of ischaemic stroke in elderly patients with symptomatic internal-carotid-artery stenosis.
Carotid endarterectomy benefits patients with symptomatic stenosis of 70-99% in the internal carotid artery, with smaller benefit for 50-69% stenosis. The benefit of carotid endarterectomy in patients of 75 years and older remains unclear. ⋯ In the prevention of ipsilateral ischaemic stroke, elderly patients with 50-99% symptomatic carotid stenosis benefited more from carotid endarterectomy than younger patients did. To achieve this treatment benefit, surgeons must be skilled and patients with other life-threatening illnesses must be excluded.
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To comprehend the results of a randomised controlled trial (RCT), readers must understand its design, conduct, analysis, and interpretation. That goal can be achieved only through total transparency from authors. Despite several decades of educational efforts, the reporting of RCTs needs improvement. ⋯ The diagram explicitly shows the number of participants, for each intervention group, included in the primary data analysis. Inclusion of these numbers allows the reader to judge whether the authors have done an intention-to-treat analysis. In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.
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Letter Randomized Controlled Trial Multicenter Study Clinical Trial
UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation: follow-up to age 4 years.
Extracorporeal membrane oxygenation (ECMO) is a supportive intensive-care technique used for babies with acute respiratory failure. We examined morbidity at age 4 years in surviving children recruited to the UK Collaborative ECMO Trial, and provide long-term data on ECMO support compared with contemporary conventional care. The neonatal ECMO policy resulted in improved survival and a favourable outcome. We therefore advocate the safety and efficacy of this intervention.
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We assessed whether wearing wide-heeled shoes has a similar effect on knee torque to narrow-heeled shoes by measuring the joint torques of 20 healthy women during walking. Wearing wide-heeled shoes had a 30% greater effect on peak external knee flexor torque than walking barefoot. Walking with wide-heeled and narrow-heeled shoes increased peak knee varus torque by 26% and 22%, respectively. Our findings imply that wide-heeled shoes cause abnormal forces across the patellofemoral and medial compartments of the knee, which are the typical anatomical sites for degenerative joint changes.