Lancet
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Liver biopsy is thought mandatory for management of patients with hepatitis C virus (HCV) infection, especially for staging fibrosis. We aimed, in our prospective study, to assess the predictive value of a combination of basic serum biochemical markers for diagnosis of clinically significant fibrosis (including early stages). ⋯ A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection.