Lancet
-
Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality. ⋯ British Heart Foundation, UK Medical Research Council, Novartis.
-
Randomized Controlled Trial Multicenter Study
Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial.
Colorectal cancer is the third most common cancer worldwide and has a high mortality rate. We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality. ⋯ Medical Research Council, National Health Service R&D, Cancer Research UK, KeyMed.