Lancet
-
Randomized Controlled Trial Multicenter Study
Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial.
Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves renal function in patients with idiopathic membranous nephropathy with declining renal function. ⋯ Medical Research Council, Novartis, Renal Association, Kidney Research UK.