Lancet
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Comment Review
Pathophysiology, research challenges, and clinical management of smoke inhalation injury.
Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. ⋯ Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.
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Severe middle cerebral artery infarction is defined as an acute infarction in the entire middle cerebral artery territory. Several case series have indicated that decompressive hemicraniectomy for severe middle cerebral artery infarction is lifesaving. However, data concerning the long-term functional outcome are insufficient. We did a systematic review and meta-analysis to assess the efficacy of decompressive hemicraniectomy for patients with severe middle cerebral artery infarction. ⋯ None.
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The role of local therapy for the management of oligometastatic prostate cancer at diagnosis still remains poorly defined. We did a systematic review and meta-analysis evaluating local therapy of the primary tumour for patients with oligometastatic prostate cancer at diagnosis as well as the patients who can benefit the most. ⋯ Local therapy for a primary tumour conferred a significantly better outcome in fit patients with oligometastatic prostate cancer at diagnosis. The evidence also suggests that radical prostatectomy is a preferable local therapy procedure for patients aged 65 years or younger or for those who have an AJCC stage M1a tumour. We believe that important local therapy factors should be systematically assessed to develop a personalised approach to improve patient survival FUNDING: This study was supported by the Prostate Cancer Foundation Young Investigator Award 2013, the National Natural Science Foundation of China (81300627 and 81370855) and Programs from Science and Technology Department of Sichuan Province (2013SZ0006 and 2014JY0219).
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With the end of 35 years of the one-child policy in China, the second-child policy presents a challenge for maternity hospitals. We aimed to inform configuration of medical resources by investigating willingness to have a second child in women with risk factors for adverse pregnancy outcomes. ⋯ None.
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Dietary patterns are reported to be influential to the risk of cardiovascular disease, but few studies have explored this among Chinese people. We aimed to examine the relationship between dietary patterns and the risk of cardiovascular diseases among the general population in Jiangsu Province, China. ⋯ Jiangsu Provincial Preventive Medicine Grant (Y2013052).