Lancet
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Homozygous familial hypercholesterolaemia is a rare life-threatening disease characterised by markedly elevated LDL cholesterol concentrations and accelerated atherosclerosis. Few studies have focused specifically on this group of patients, especially in China. We set out to investigate the phenotypical characteristics and the genotype-phenotype correlations of homozygous familial hypercholesterolaemia in China. ⋯ National Natural Science Foundation of China (number 81471098).
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Coronary heart disease is the leading global cause of death, and e-health web-based programmes are effective to support patients. However, fewstudieshave reported psychological outcomes and health related quality of life (HRQoL) in Chinese populations. This study aimed to investigate the effect of an e-health web-based support programme for patients with coronary heart disease on anxiety, depression, and HRQoL across six months. ⋯ Health and Medical Research Fund, Food and Health Bureau of Hong Kong.
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Endothelial progenitor cells (EPCs) derived from bone marrow are associated with the repair of vascular injury by accelerating re-endothelisation, and represent a potential therapeutic target for ischaemic disease. Danhong injection (DHI), a Chinese Materia Medica standardised product extracted from Radix Salvia miltiorrhiza and Flos Carthamus tinctorius L, is effective in the treatment of ischaemic heart disease. We assessed the effect of DHI on the mobilisation of EPCs and vascular repair mediated by EPCs after percutaneous coronary intervention (PCI). ⋯ China National Basic Research Program (973 programme, number 2012CB518404).
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HIV and syphilis epidemics in men who have sex with men (MSM) continue to grow in China, despite considerable government attention. We did a literature review to synthesise key features of the HIV and syphilis epidemics and responses among MSM and transgender individuals in China. Our goal was to inform evidence-based recommendations for policy makers and program managers. ⋯ US National Institute of Allergy and Infectious Diseases (NIAID; 1R01AI114310); University of North Carolina (UNC)-South China Sexually Transmitted Disease Research Training Centre (Fogarty International Centre (FIC); 1D43TW009532); UNC Center for AIDS Research (NIAID; 5P30AI050410); the UNC Chapel Hill, Johns Hopkins University, Morehead School of Medicine and Tulane University (UJMT) Fogarty Fellowship (FIC; R25TW0093); WHO-China.
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Both ketamine and methamphetamine have been used for studying the positive, negative, and cognitive symptoms, and dopaminergic and GABAergic dysfunction observed in acute schizophrenia. We aimed to explore and compare the prevalence and factor structure of psychotic symptoms in chronic ketamine and methamphetamine users. ⋯ Natural Science Foundation of China (81100996 to YL, and 81371480 to JT). The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding authors had full access to all the data in the study and had final responsibility for the decision to submit for publication.