Lancet
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Multicenter Study
Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study.
Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries. ⋯ Full funding sources listed at end of paper (see Acknowledgments).
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Randomized Controlled Trial Multicenter Study Comparative Study
Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial.
The international standard of care for women with suspected advanced ovarian cancer is surgical debulking followed by platinum-based chemotherapy. We aimed to establish whether use of platinum-based primary chemotherapy followed by delayed surgery was an effective and safe alternative treatment regimen. ⋯ Cancer Research UK and the Royal College of Obstetricians and Gynaecologists.