Lancet
-
Randomized Controlled Trial Clinical Trial
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.
Despite the use of aspirin, there is still a risk of ischaemic events after percutaneous coronary intervention (PCI). We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI. ⋯ In patients with acute coronary syndrome receiving aspirin, a strategy of clopidogrel pretreatment followed by long-term therapy is beneficial in reducing major cardiovascular events, compared with placebo.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial.
Survival rates for cardiac arrest patients, both in and out of hospital, are poor. Results of a previous study suggest better outcomes for patients treated with vasopressin than for those given epinephrine, in the out-of-hospital setting. Our aim was to compare the effectiveness and safety of these drugs for the treatment of in-patient cardiac arrest. ⋯ We failed to detect any survival advantage for vasopressin over epinephrine. We cannot recommend the routine use of vasopressin for inhospital cardiac arrest patients, and disagree with American Heart Association guidelines, which recommend vasopressin as alternative therapy for cardiac arrest.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: a randomised controlled trial.
Low-concentration bupivacaine epidurals for labor analgesia result in a lower-incidence of instrumental delivery than 'traditional' high-dose bupivacaine epidurals.
pearl -
Randomized Controlled Trial Comparative Study Clinical Trial
Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial.
Currently available treatments for moderate to severe psoriasis are either incompletely effective in some patients, or are associated with toxic effects. Since tumour necrosis factor alpha (TNF-alpha) is thought to have a role in the pathogenesis of psoriasis, we did a double-blind, randomised trial to assess the clinical benefit and safety of infliximab-a monoclonal antibody against TNF-alpha. ⋯ In this controlled trial, patients receiving the anti-TNF-alpha agent infliximab as monotherapy experienced a high degree of clinical benefit and rapid time to response in the treatment of moderate to severe plaque psoriasis compared with patients who received placebo. These findings suggest that TNF-alpha has a pivotal role in the pathogenesis of psoriasis.
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
WHO antenatal care randomised trial for the evaluation of a new model of routine antenatal care.
We undertook a multicentre randomised controlled trial that compared the standard model of antenatal care with a new model that emphasises actions known to be effective in improving maternal or neonatal outcomes and has fewer clinic visits. ⋯ Provision of routine antenatal care by the new model seems not to affect maternal and perinatal outcomes. It could be implemented without major resistance from women and providers and may reduce cost.