Lancet
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Randomized Controlled Trial
The Peer Education Project to improve mental health literacy in secondary school students in England: a qualitative realist evaluation.
Worsening of adolescent mental health and exacerbated health inequalities after the COVID-19 pandemic calls for universal preventative strategies. The Mental Health Foundation's school-based Peer Education Project seeks to improve students' mental health literacy through peer educators (aged 14-18 years) teaching peer learners (aged 11-13 years) to recognise good and bad mental health, identify risk and protective factors, and seek help accordingly. Although previous before and after quantitative assessments have found the intervention to be effective, this realist evaluation aimed to qualitatively develop the theory of change, exploring how the mechanisms played out in different contexts to achieve the desired outcomes. ⋯ National Institute for Health and Care Research School for Public Health Research.
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Randomized Controlled Trial
Midwives' survey of weight management practices before and after implementation of the GLOWING guideline: a pilot, cluster, randomised controlled trial.
Maternal weight management increases risks for women and babies and is a public health priority. Interventions can substantially improve maternal diet and physical activity behaviours and pregnancy outcomes. Low self-efficacy is a core barrier to midwives' implementation of guidelines. GLOWING used social cognitive theory to address evidence-based barriers to practice, aiming to support midwives' guidelines implementation. ⋯ National Institute for Health Research Postdoctoral Fellowship (reference PDF-2011-04-034).
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Randomized Controlled Trial Observational Study
Evaluation of the real-world implementation of the Family Nurse Partnership in England: an observational cohort study using linked data from health, education, and children's social care.
The Family Nurse Partnership (FNP) is an early home visiting service supporting young mothers. A randomised controlled trial of FNP in England found no effect on short-term primary outcomes or maltreatment in children up to age 7 years, but positive impacts on some educational outcomes. We report preliminary results of a national evaluation of FNP using linked administrative data. ⋯ National Institute for Health and Care Research.
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Randomized Controlled Trial
Evaluating the Change4Life Food Scanner app in reducing children's sugar intake: a randomised pilot and feasibility study.
The Change4Life Food Scanner app displays nutritional information using visual images alongside traffic light labels. The app's effectiveness for improving dietary choices is unknown. This study investigated the feasibility and acceptability of evaluating the effectiveness of the Food Scanner app in reducing children's sugar intake in the UK. ⋯ Wellcome Trust.
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Randomized Controlled Trial Multicenter Study
9 months of delamanid, linezolid, levofloxacin, and pyrazinamide versus conventional therapy for treatment of fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-END): a multicentre, randomised, open-label phase 2/3 non-inferiority trial in South Korea.
With the introduction of new anti-tuberculosis drugs, all-oral regimens with shorter treatment durations for multidrug-resistant tuberculosis have been anticipated. We aimed to investigate whether a new all-oral regimen was non-inferior to the conventional regimen including second-line anti-tuberculosis drugs for 20-24 months in the treatment of fluoroquinolone-sensitive multidrug-resistant tuberculosis. ⋯ Korea Disease Control and Prevention Agency, South Korea.