Medicine
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Premature ejaculation is a common sexual dysfunction disease in adult males. It can be divided into primary and secondary premature ejaculation. Acupuncture is widely used in the treatment of premature ejaculation in China. There are many clinical trials confirmed that acupuncture can prolong the ejaculation latency in the vagina. We aim to use a meta-analysis to evaluate the efficacy and safety of acupuncture for premature ejaculation. ⋯ PROSPERO CRD42018092783.
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Randomized Controlled Trial
Effect of the curved blade size on the outcomes of tracheal intubation performed by incoming interns: A randomized controlled manikin study.
Novice clinicians who have little or no clinical experience in tracheal intubation occasionally need a long time to perform the procedure when using a large curved blade. They also have a lower tracheal intubation success rate, especially in emergency situations, such as cardiac arrest, than experienced practitioners. This study aimed to investigate whether the size of the curved laryngoscope blade affects the outcomes of tracheal intubation performed by incoming interns on a manikin model. ⋯ The outcomes of direct orotracheal intubation performed by novice practitioners may be influenced by the blade's size. Significant emphasis should be given on key anatomical landmarks and progressive visualization for tracheal intubation during airway management training for novice clinicians.
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The association between use of non-vitamin K antagonist oral anticoagulants (NOACs) with cognitive impairment in atrial fibrillation (AF) remains unknown. ⋯ CRD42018103849.
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Thrombocytopenia caused by linezolid (LZD) is common, with a reported prevalence as high as 11.8%. Platelets typically reach normal levels 7 days after LZD withdrawal. However, recurrent profound thrombocytopenia due to LZD usage and a persistent profound drop in platelet count after LZD withdrawal have not been reported. ⋯ Recurrent profound thrombocytopenia can happen after several doses of LZD rechallenging. Therefore, reuse of LZD should be avoided after recovery from severe thrombocytopenia due to LZD.
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Comparative Study
Peritoneal dialysis in older adults: Evaluation of clinical, nutritional, metabolic outcomes, and quality of life.
The number of older adults requiring dialysis is increasing worldwide, whereas the use of peritoneal dialysis (PD) in this population is lower with respect to younger patients, despite the theoretical advantages of PD respect to hemodialysis. This is most likely due to the concern that older patients may not be able to correctly and safely manage PD. We aimed to prospectively compare clinical, nutritional and metabolic outcomes and measures of quality of life between younger (<65 years old) and older (≥65 years old) patients on PD. ⋯ At T1 Group B showed, compared to baseline, a significant reduction in albumin (P < .0001) and phosphorus (P = .045) levels, while no significant differences on body composition, technique survival, total number of hospitalizations, index of peritonitis, and quality of life indices were observed. Our data do not show clinically relevant barriers to use PD in older adult patients, supporting its use in this population. Nutritional and metabolic parameters should be carefully monitored in older PD patients.