Medicine
-
Meta Analysis Comparative Study
Vonoprazan versus proton pump inhibitors for the management of gastroesophageal reflux disease: A protocol for a systematic review with meta-analysis.
Vonoprazan, a novel potassium-competitive acid blocking agent, is used in the management of gastroesophageal reflux disease (GERD). We aim to perform a systematic review and meta-analysis for the comparison of the effects of vonoprazan and proton pump inhibitors (PPIs) in GERD in randomized controlled trials (RCTs). ⋯ To our knowledge, this systematic review and meta-analysis will be the first to evaluate existing research comparing Vonoprazan and PPIs in GERD. Our study will provide information about the effect of vonoprazan and PPIs in GERD in RCTs. The review will benefit patients, healthcare providers, and policymakers.
-
Hemangioblastoma is a rare tumor of the central nervous system (CNS). It is usually observed in patients with von-Hippel Lindau (VHL). The peak age for hemangioblastoma is between 20 and 50 years of age with very few cases over 65 or below 18 years of age. ⋯ The unique feature of our case is the presence of multiple drop-metastases like spinal lesions, which has not been reported in the literature to be associated with hemangioblastoma.
-
Comparative Study
Hope as a behavior and cognitive process: A new clinical strategy about mental health's prevention.
Given the aging population, it is necessary to develop strategies for the prevention and promotion of mental health in the elderly. Hope as the ability to trace and maintain paths can be used as a key construct for these strategies, promoting cognitive health if stimulated. ⋯ Hope in addition to cognitive stimulation shows more significant results in elderly people at initial stimulation (0.18), mainly at the permanence and troubleshooting on the paths concerned; this corresponds with the results obtained for hope (0.18). Depressive symptomatology showed significant differences among the 2 groups (0.39 and 0.02). In the between-groups comparisons, only GDS showed significance (0.46).Hope training has an impact on the remission of depressive symptoms and, despite increased hope levels, training was effective for the reduction of depression symptoms for up to 6 months, thereafter only playing a maintenance role. Broadly, hope has been shown to promote elderly people's mental health.
-
Observational Study
Neonate female to male ratio after assisted reproduction following antagonist and agonist protocols.
We retrospectively compared neonatal sex after antagonist- versus long-stimulation protocols followed by fresh in vitro fertilization (IVF) or fresh intracytoplasmic sperm injection (ICSI) with either protocol. We reviewed data for 762 IVF/ICSI cycles in 2015, including 23 IVF procedures. ⋯ Our results also showed no significant difference in sex proportion when comparing IVF versus ICSI, although a higher proportion of babies were male with the antagonist-ICSI protocol. Differences between the additional subgroups were also neither clinically nor statistically significant.
-
Review Meta Analysis
Polymorphism of R353Q (rs6046) in factor VII and the risk of myocardial infarction: A systematic review and meta-analysis.
Genetic components substantially contribute to the development of myocardial infarction (MI), and R353Q polymorphism (rs6046) in FVII gene has been suspected to be associated with the risk of MI. ⋯ The current meta-analysis suggested that R353Q polymorphism was not associated with the MI risk. Asian population, BMI category, and diabetes might be related to the incidence of MI. However, large-scale, case-control studies with rigorous designs are essential to provide accurate evidence.