Medicine
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Hereditary motor-sensory peripheral neuropathy, or Charot-Marie-Tooth (CMT) Charcot-Marie-Tooth disease is an inherited peripheral neuropathy characterized by progressive limb weakness and muscle atrophy. As the disease progresses, sensory and autonomic involvement may occur. We report a case of CMT associated with SOD1 gene mutation, in order to provide new ideas for clinical disease diagnosis. ⋯ The clinical manifestations and electromyography results of this patient are consistent with the characteristics of CMT. The peripheral nerve-related hereditary gene test found mutation in SOD1. It is possible that this mutation is linked to CMT. The disease is a neurodegenerative disease, that may be slowed by physical therapy and rehabilitation, but could not be healed.
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To investigate the role of serum spalt like transcription factor 4 (SALL4) in the hepatocellular carcinoma (HCC) patients with nonsurgical treatment. Serum samples were collected from 101 patients with HCC without surgical treatment, then the SALL4 was detected by enzyme linked immunosorbent assay. According to subsequent treatment, patients were divided into 2 groups, best supportive care (BSC) (58 cases) and nonsurgical anticancer treatment (NSAT) (48 cases). ⋯ In NSAT group, the survival time of patients with low SALL4 concentration was significantly longer than patients with high SALL4 concentration (P = .005). SALL4 have no predictive effect in BSC patients with HCC. But for patients received NSAT, low SALL4 concentration in serum may indicate longer survival.
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To evaluate the correlation between mean platelet volume (MPV) and obstructive sleep apnea-hypopnea syndrome (OSAHS) in children, and to explore the diagnostic value of MPV for OSAHS. Children with OSAHS diagnosed by polysomnography (PSG) at Fuyong People's Hospital of Bao'an District/Shenzhen Children's Hospital from January 2020 to January 2021 were enrolled in this study. MPV in peripheral venous blood of the enrolled children was detected. ⋯ The critical value was 8.85 fl, and the coincidence rates for these 2 conditions were 96.4% and 76.3%, respectively. In children with OSAHS, MPV is positively correlated with AHI and negatively correlated with the LSaO2 index of PSG. Based on the results of ROC curve analysis, MPV can be used as an auxiliary diagnostic index to judge the severity of OSAHS and the degree of hypoxia in children.
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As we all know, this Nobel Prize is awarded to uncover the mechanism of "a glass of cold milk providing instant relief when eating a spicy hot pot"; the key factor, Piezo, has therefore become a clinical research hotspot. Most importantly, the factor of Piezo has been increasingly considered when analyzing the majority of common clinical diseases. The Piezo has entered a new stage and has made a series of progress. This study mainly outlines the knowledge map and detects the potential research hotspots by using bibliometric analysis. ⋯ Piezo is rapidly developing. This knowledge will be utilized extensively in the process of developing treatments for many diseases. Current research focuses mostly on gene expression.
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We previously reported that oral herpesviruses, such as Epstein-Barr virus (EBV), are associated with periodontitis. However, the relationship between oral EBV or dual oral EBV and Porphyromonas gingivalis infections and periodontal inflammation severity remains unclear. We conducted this study to determine the relationship between oral EBV and P gingivalis prevalence and the periodontal inflamed surface area (PISA) in middle-aged and older adults. ⋯ Logistic regression analysis revealed that dual infection with EBV and P gingivalis was significantly associated with diabetes (odds ratio = 3.37, 95% confidence interval: 1.13-10.1; P = .03). Oral EBV prevalence is associated with oral hygiene and the spread of inflamed periodontal tissue. Diabetes may be a risk factor for dual infection with oral EBV and P gingivalis.