Medicine
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To explore whether season is a risk factor of periprosthetic joint infection (PJI) after total joint arthroplasty (TJA) and explain it with the theory of traditional Chinese medicine. This was a retrospective cohort study. Only patients who suffered from PJI within 1 month after TJA were included in the study. ⋯ Late summer was an independent risk factor of PJI after TJA. The infection rate of PJI after TJA in late summer is higher than other seasons. A more thorough preoperative disinfection procedure is needed in late summer.
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Observational Study
Nursing effect of continuous nursing intervention based on "Internet Plus" on patients with severe adrenal tumor.
Adrenal tumors are a common type of tumor whose incidence increases with age. This study aims to apply the continuous nursing mode of "Internet Plus" to patients with severe adrenal tumors, and preliminarily evaluate the nursing effect of continuous nursing intervention based on "Internet Plus" on patients with severe adrenal tumors. A single-center, retrospective, observational study was carried out on severe adrenal tumor patients. ⋯ The first time to get out of bed (t = 10.64, 95% confidence interval [CI] = 5.32-16.53, P < .001), upper limb swelling to subside time (t = 16.50, 95% CI = 7.21-26.15, P < .001) and the length of hospital stay (t = 11.82, 95% CI = 5.61-17.95, P < .001) were significantly shorter, 72 hours postoperative sleep time (t = 9.46, 95% CI = 4.93-15.48, P < .001) was significantly longer, and the visual analog scale score of 72 hours after operation (t = 15.95, 95% CI = 7.32-24.09, P < .001) was significantly lower in the observation group than that in the control group. After receiving nursing intervention, the scores of somatization (t = 17.56, 95% CI = 9.51-27.96, P < .001), anxiety (t = 21.85, 95% CI = 12.35-33.71, P < .001), depression (t = 18.29, 95% CI = 9.63-28.22, P < .001), self-rating anxiety scale (t = 33.67, 95% CI = 19.65-46.13, P < .001), self-rating depression scale (t = 31.92, 95% CI = 20.73-45.88, P < .001), and the quality of life score (t = 21.54, 95% CI = 8.92-40.37, P < .001) were significantly lower, and the positive coping (t = 16.30, 95% CI = 5.15-18.14, P < .001) and negative coping (t = 20.54, 95% CI = 9.34-33.12, P < .001) scores were significantly higher in the observation group than those in the control group. Nursing intervention based on "Internet Plus" continuous mode can promote the recovery of physical function, reduce psychological pressure and negative emotions, and then improve the quality of life of severe adrenal tumor patients.
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Obesity is detrimental to general health and also reproductive health. This study aimed to evaluate whether weight reduction in obese infertile women prior to in vitro fertilization reduces the total gonadotropin dose and improves pregnancy outcomes. This retrospective cohort study was performed at the Jiaxing Maternity and Child Health Care Hospital between January 2017 and January 2022, and 197 women were enrolled. ⋯ Weight loss (≥5%) lasting 3 to 6 months did not improve the clinical pregnancy and live birth rates. However, weight loss (≥5%) can decrease the total gonadotropin dose in obese women scheduled for in vitro fertilization. Weight loss of up to 10% can significantly decrease the total gonadotropin dose, improve the clinical pregnancy rate, and increase the live birth rate.
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The present study intends to investigate the correlation between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and postoperative cognitive dysfunction (POCD) in elderly patients with esophageal cancer. Elderly patients >65 years old with esophageal cancer in our department from October 2017 to June 2021 were included in the study. The cognitive function of the patients was assessed by the mini-mental state examination (MMSE) Scale at 1day, 3 days, and 7days after surgery. ⋯ After combination of NLR and PLR, the AUC increased to 0.803 with the sensitivity of 66.7% and specificity of 82.5%. The expression level of postoperative NLR and PLR in elderly patients with esophageal cancer combined with POCD is significantly increased, which is associated with postoperative cognitive impairment. Moreover, the combination of NLR and PLR has a good predictive ability for POCD, which could be used as a potential biomarker for early diagnosis of POCD.
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Lung cancer is one of the most prevalent cancers and the leading cause of cancer-related deaths worldwide; non-small cell lung cancer (NSCLC) comprises approximately 80% of all lung cancer cases. This study aimed to construct a competing endogenous RNA (ceRNA) network and identify prognostic signatures in elderly patients with NSCLC. ⋯ This study provides novel insights into the lncRNA-miRNA-mRNA ceRNA network and reveals potential biomarkers for the diagnosis and prognosis of elderly patients with NSCLC.