Medicine
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Meta Analysis
Interleukin-10 is not associated with obstructive sleep apnea hypopnea syndrome: A meta-analysis and meta-regression.
This study was conducted to explore the potential relationship between interleukin-10 (IL-10) and obstructive sleep apnea hypopnea syndrome (OSAHS). ⋯ The current meta-analysis highlighted that IL-10 levels between patients with OSAHS and healthy people had no difference.
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The field of critical care-related artificial intelligence (AI) research is rapidly gaining interest. However, there is still a lack of comprehensive bibliometric studies that measure and analyze scientific publications on a global scale. Network charts have traditionally been used to highlight author collaborations and coword phenomena (ACCP). It is necessary to determine whether chord network charts (CNCs) can provide a better understanding of ACCP, thus requiring clarification. This study aimed to achieve 2 objectives: evaluate global research trends in AI in intensive care medicine on publication outputs, coauthorships between nations, citations, and co-occurrences of keywords; and demonstrate the use of CNCs for ACCP in bibliometric analysis. ⋯ This study provides valuable insights into the potential for ACCP and future research opportunities. For AI-based clinical research to become widely accepted in critical care practice, collaborative research efforts are necessary to strengthen the maturity and robustness of AI-driven models using CNCs for display.
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Randomized Controlled Trial
Hypertonic glucose in the treatment of low back pain: A randomized clinical trial.
Chronic low back pain (LBP) is defined as pain lasting longer than 3 months and is one of the conditions with the most significant social impact. Treatment is complex and includes proliferative agents used in prolotherapy. The mechanism is not known, but osmotic agents (hypertonic solutions of dextrose or glucose) cause cellular rupture and an inflammatory response that releases cytokines and growth factors that lead to scarring and reinnervation. ⋯ Both groups significantly improved on the evaluated scales during follow-up. Overall, no effects were attributable to the glucose components or the prolotherapy protocol.
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Multicenter Study
The dose of focused ultrasound ablation surgery (FUAS) for unresectable pancreatic cancer is predictable: A multicenter retrospective study.
To analyze the influencing factors of energy efficiency factors (EEF) in focused ultrasound ablation surgery (FUAS) for unresectable pancreatic cancer and build a dosimetry model. The patients with unresectable pancreatic cancer that underwent FUAS were enrolled from 3 clinical centers between June 2015 and June 2022 for retrospective analysis. ⋯ The resultant multiple regression models of EEF achieved significance, contains predictors of Tumor volume, the distance from tumor center to skin, T2-weighted imaging fat suppression signal intensity, and contrast-enhanced T1-weighted imaging enhancement type had better goodness of fit. Compared with CT, the EEF prediction model established by adding magnetic resonance imaging features showed better prediction in FUAS treatment of unresectable pancreatic cancer.
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Proton pump inhibitors (PPIs) are among the most prescribed and widely used medications; however, the long-term effects of these medications are only beginning to be investigated. Since the introduction of omeprazole in 1989, PPIs have become the first-choice treatment for esophagitis, peptic ulcer disease, Zoster-Ellison syndrome, dyspepsia, and the prevention of ulcers with non-steroidal anti-inflammatory drugs. Recent studies have specifically examined the rise in celiac disease (CD) in this context. ⋯ Recent studies have suggested that the rise in CD could be attributed to changes in the gut microbiome, highlighting the significant role that gut microbiota is proposed to play in CD pathogenesis. Although PPI therapy is helpful in reducing acid production in gastroesophageal disorders, additional information is needed to determine whether PPIs are still an appropriate treatment option with the possibility of developing CD in the future, particularly in the context of HLA-DQ2 and HLA-DQ8 predispositions. This review emphasizes the importance of personalized medicine for individuals with gastroesophageal disorders that require long-term use of PPIs.